Results 131 to 140 of about 1,107,991 (320)

An integrative analysis of genome-wide association study and regulatory SNP annotation datasets identified candidate genes for bipolar disorder

International Journal of Bipolar Disorders, 2020
Background Bipolar disorder (BD) is a complex mood disorder. The genetic mechanism of BD remains largely unknown. Methods We conducted an integrative analysis of genome-wide association study (GWAS) and regulatory SNP (rSNP) annotation datasets ...
Xin Qi, Yan Wen, Ping Li, Chujun Liang, Bolun Cheng, Mei Ma, Shiqiang Cheng, Lu Zhang, Li Liu, Om Prakash Kafle, Feng Zhang   +10 more
doaj   +1 more source

A scientometric review of genome-wide association studies

Communications Biology, 2019
This scientometric review of genome-wide association studies (GWAS) from 2005 to 2018 (3639 studies; 3508 traits) reveals extraordinary increases in sample sizes, rates of discovery and traits studied.
M. Mills, C. Rahal
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Nature Communications, 2019
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association ...
C. Nievergelt, A. Maihofer, T. Klengel, Elizabeth G. Atkinson, Chia-Yen Chen, Karmel W. Choi, J. Coleman, S. Dalvie, L. Duncan, J. Gelernter, D. Levey, M. Logue, R. Polimanti, Allison Provost, A. Ratanatharathorn, M. Stein, Katy Torres, A. Aiello, L. Almli, A. Amstadter, S. Andersen, O. Andreassen, P. Arbisi, A. Ashley-Koch, S. Austin, E. Avdibegović, D. Babic, Marie Bækvad-Hansen, D. Baker, J. Beckham, L. Bierut, J. Bisson, M. Boks, Elizabeth A. Bolger, A. Børglum, B. Bradley, M. Brashear, G. Breen, R. Bryant, A. Bustamante, J. Bybjerg-Grauholm, J. Calabrese, J. Caldas-de-Almeida, A. Dale, M. Daly, N. Daskalakis, J. Deckert, D. Delahanty, Michelle F. Dennis, S. Disner, K. Domschke, A. Dzubur-Kulenovic, Christopher R. Erbes, Alexandra Evans, L. Farrer, N. Feeny, J. Flory, D. Forbes, C. Franz, S. Galea, M. Garrett, B. Gelaye, E. Geuze, Charles F. Gillespie, A. Uka, S. Gordon, G. Guffanti, R. Hammamieh, Supriya Harnal, M. Hauser, A. Heath, S. Hemmings, D. Hougaard, M. Jakovljevič, M. Jett, Eric O. Johnson, I. Jones, T. Jovanović, X. Qin, A. Junglen, Karen-Inge Karstoft, M. Kaufman, R. Kessler, Alaptagin Khan, N. Kimbrel, A. King, N. Koen, H. Kranzler, W. Kremen, B. Lawford, L. Lebois, Catrin E Lewis, S. Linnstaedt, A. Lori, B. Lugonja, Jurjen J. Luykx, M. Lyons, J. Maples-Keller, C. Marmar, Alicia R. Martin, N. Martin, D. Maurer, M. Mavissakalian, A. McFarlane, R. McGlinchey, K. McLaughlin, S. Mclean, S. Mcleay, D. Mehta, W. Milberg, Mark W. Miller, R. Morey, C. P. Morris, O. Mors, P. Mortensen, B. Neale, E. Nelson, M. Nordentoft, S. Norman, M. O'Donnell, H. Orcutt, M. Panizzon, E. Peters, A. Peterson, Matthew Peverill, R. Pietrzak, Melissa A. Polusny, J. Rice, S. Ripke, V. Risbrough, A. Roberts, Alex O. Rothbaum, B. Rothbaum, P. Roy-Byrne, K. Ruggiero, A. Rung, B. Rutten, N. Saccone, S. Sanchez, D. Schijven, S. Seedat, Antonia V. Seligowski, J. Seng, Christina M. Sheerin, D. Silove, Alicia K. Smith, J. Smoller, S. Sponheim, Dan J Stein, Jennifer S Stevens, J. Sumner, Martin H. Teicher, W. Thompson, E. Trapido, M. Uddin, R. Ursano, L. L. van den Heuvel, M. Van hooff, E. Vermetten, C. Vinkers, J. Voisey, Yunpeng Wang, Zhewu Wang, T. Werge, Michelle A Williams, D. Williamson, S. Winternitz, C. Wolf, E. Wolf, Jonathan D Wolff, R. Yehuda, R. Young, K. Young, Hongyu Zhao, L. Zoellner, I. Liberzon, K. Ressler, M. Haas, K. Koenen   +178 more
semanticscholar   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays

G3: Genes, Genomes, Genetics, 2019
Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers.
Karl A. G. Kremling, Christine H. Diepenbrock, Michael A. Gore, Edward S. Buckler, Nonoy B. Bandillo   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Genome-wide association studies with metabolomics [PDF]

Genome Medicine, 2012
Genome-wide association studies (GWAS) analyze the genetic component of a phenotype or the etiology of a disease. Despite the success of many GWAS, little progress has been made in uncovering the underlying mechanisms for many diseases. The use of metabolomics as a readout of molecular phenotypes has enabled the discovery of previously undetected ...
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source