Results 71 to 80 of about 1,107,991 (320)
Genome-wide association studies in cancer [PDF]
Human Molecular Genetics, 2008 Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that ...
Douglas F, Easton, Rosalind A, Eeles
openaire +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Single-Locus and Multi-Locus Genome-Wide Association Studies for Intramuscular Fat in Duroc Pigs
Frontiers in Genetics, 2019 Intramuscular fat (IMF) is an important quantitative trait of meat, which affects the associated sensory properties and nutritional value of pork. To gain a better understanding of the genetic determinants of IMF, we used a composite strategy, including ...
Rongrong Ding +14 more
doaj +1 more source
Frontiers in Genetics, 2022 Objective: We identify and explore the candidate susceptibility genes for cirrhosis and their underlying biological mechanism.Methods: We downloaded the genome-wide association studies summary data of 901 cirrhosis cases and 451,363 controls and ...
Xiao-Bo Zhu +7 more
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A tutorial on conducting genome‐wide association studies: Quality control and statistical analysis
International Journal of Methods in Psychiatric Research, 2018 Genome‐wide association studies (GWAS) have become increasingly popular to identify associations between single nucleotide polymorphisms (SNPs) and phenotypic traits. The GWAS method is commonly applied within the social sciences.
A. Marees +6 more
semanticscholar +1 more source
Genome-wide gene-based association study [PDF]
BMC Proceedings, 2009 Genome-wide association studies, which analyzes hundreds of thousands of single-nucleotide polymorphisms to identify disease susceptibility genes, are challenging because the work involves intensive computation and complex modeling. We propose a two-stage genome-wide association scanning procedure, consisting of a single-locus association scan for the ...
Yang, Hsin-Chou +4 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Experimental GerontologyBackground: Genome-wide association studies (GWAS) have revealed numerous loci associated with multiple sclerosis (MS). However, the challenge lies in deciphering the mechanisms by which these loci influence the target traits.
Yi Liu +7 more
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The Human Microbiome and the Missing Heritability Problem
Frontiers in Genetics, 2017 The “missing heritability” problem states that genetic variants in Genome-Wide Association Studies (GWAS) cannot completely explain the heritability of complex traits.
Santiago Sandoval-Motta +6 more
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Gene-centric characteristics of genome-wide association studies. [PDF]
PLoS ONE, 2007 BACKGROUND: The high-throughput genotyping chips have contributed greatly to genome-wide association (GWA) studies to identify novel disease susceptibility single nucleotide polymorphisms (SNPs).
Changzheng Dong +5 more
doaj +1 more source