Results 31 to 40 of about 1,107,991 (320)

Turning genome-wide association study findings into opportunities for drug repositioning

Computational and Structural Biotechnology Journal, 2020
Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much reduced cost.
Alexandria Lau, Hon-Cheong So
doaj   +1 more source

SNP set association analysis for genome-wide association studies. [PDF]

PLoS ONE, 2013
Genome-wide association study (GWAS) is a promising approach for identifying common genetic variants of the diseases on the basis of millions of single nucleotide polymorphisms (SNPs).
Min Cai, Hui Dai, Yongyong Qiu, Yang Zhao, Ruyang Zhang, Minjie Chu, Juncheng Dai, Zhibin Hu, Hongbing Shen, Feng Chen   +9 more
doaj   +1 more source

Genome-Wide Association Studies [PDF]

, 2015
Over the last twenty years, genome-wide association studies (GWAS) have revealed a great deal about the genetic basis of a wide range of complex diseases and they will undoubtedly continue to have a broad impact as we move to an era of personalised medicine.
Stephen W. Scherer, Peter M. Visscher
openaire   +2 more sources

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

BMC Bioinformatics, 2012
Background Genome-wide association studies (GWAS) with metabolic traits and metabolome-wide association studies (MWAS) with traits of biomedical relevance are powerful tools to identify the contribution of genetic, environmental and lifestyle factors to ...
Petersen Ann-Kristin, Krumsiek Jan, Wägele Brigitte, Theis Fabian J, Wichmann H-Erich, Gieger Christian, Suhre Karsten   +6 more
doaj   +1 more source

Optimized homomorphic encryption solution for secure genome-wide association studies

BMC Medical Genomics, 2020
Background Genome-Wide Association Studies (GWAS) refer to observational studies of a genome-wide set of genetic variants across many individuals to see if any genetic variants are associated with a certain trait.
Marcelo Blatt, Alexander Gusev, Yuriy Polyakov, Kurt Rohloff, Vinod Vaikuntanathan   +4 more
doaj   +1 more source

Genome-wide association studies in Plasmodium species [PDF]

, 2010
Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be ...
Bridget Penman, Caroline Buckee, Sean Nee, Sunetra Gupta   +3 more
core   +3 more sources

An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank

Nature Neuroscience, 2021
UK Biobank is a major prospective epidemiological study, including multimodal brain imaging, genetics and ongoing health outcomes. Previously, we published genome-wide associations of 3,144 brain imaging-derived phenotypes, with a discovery sample of 8 ...
Stephen M. Smith, G. Douaud, Winfield Chen, Taylor Hanayik, F. Alfaro-Almagro, Kevin Sharp, L. Elliott   +6 more
semanticscholar   +1 more source

New approaches to population stratification in genome-wide association studies

Nature Reviews Genetics, 2010
A. Price, N. Zaitlen, D. Reich, N. Patterson   +3 more
semanticscholar   +3 more sources

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

Nucleic Acids Res., 2016
The NHGRI-EBI GWAS Catalog has provided data from published genome-wide association studies since 2008. In 2015, the database was redesigned and relocated to EMBL-EBI.
J. MacArthur, Emily Bowler, M. Cerezo, Laurent Gil, Peggy Hall, Emma Hastings, Heather Junkins, A. McMahon, Annalisa Milano, Joannella Morales, Z. Pendlington, Danielle Welter, Tony Burdett, L. Hindorff, P. Flicek, Fiona Cunningham, H. Parkinson   +16 more
semanticscholar   +1 more source

SNPpy--database management for SNP data from genome wide association studies. [PDF]

PLoS ONE, 2011
We describe SNPpy, a hybrid script database system using the Python SQLAlchemy library coupled with the PostgreSQL database to manage genotype data from Genome-Wide Association Studies (GWAS). This system makes it possible to merge study data with HapMap
Faheem Mitha, Herodotos Herodotou, Nedyalko Borisov, Chen Jiang, Josh Yoder, Kouros Owzar   +5 more
doaj   +1 more source