Results 21 to 30 of about 22,469,227 (260)

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes [PDF]

open access: yes, 2014
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies ...
Rasmussen-Torvik, Laura J.   +585 more
core   +2 more sources

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

open access: yesBMC Bioinformatics, 2012
Background Genome-wide association studies (GWAS) with metabolic traits and metabolome-wide association studies (MWAS) with traits of biomedical relevance are powerful tools to identify the contribution of genetic, environmental and lifestyle factors to ...
Petersen Ann-Kristin   +6 more
doaj   +1 more source

Turning genome-wide association study findings into opportunities for drug repositioning

open access: yesComputational and Structural Biotechnology Journal, 2020
Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much reduced cost.
Alexandria Lau, Hon-Cheong So
doaj   +1 more source

SNP set association analysis for genome-wide association studies. [PDF]

open access: yesPLoS ONE, 2013
Genome-wide association study (GWAS) is a promising approach for identifying common genetic variants of the diseases on the basis of millions of single nucleotide polymorphisms (SNPs).
Min Cai   +9 more
doaj   +1 more source

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis [PDF]

open access: yes, 2011
Objectives: To investigate if potential common pathways exist for the pathogenesis of autoimmune disease and prostate cancer (PrCa). To ascertain if the single nucleotide polymorphisms (SNPs) reported by genome-wide association studies (GWAS) as being ...
Donovan, Jenny   +58 more
core   +1 more source

Optimized homomorphic encryption solution for secure genome-wide association studies

open access: yesBMC Medical Genomics, 2020
Background Genome-Wide Association Studies (GWAS) refer to observational studies of a genome-wide set of genetic variants across many individuals to see if any genetic variants are associated with a certain trait.
Marcelo Blatt   +4 more
doaj   +1 more source

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

open access: yes, 2011
To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-
Richard W. Morris   +147 more
core   +1 more source

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies [PDF]

open access: yes, 2012
<p>Background - Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less.
Furie, K.   +403 more
core   +2 more sources

A genome-wide association search for type 2 diabetes genes in African Americans. [PDF]

open access: yes, 2012
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Kumari, Meena   +389 more
core   +3 more sources

SNPpy--database management for SNP data from genome wide association studies. [PDF]

open access: yesPLoS ONE, 2011
We describe SNPpy, a hybrid script database system using the Python SQLAlchemy library coupled with the PostgreSQL database to manage genotype data from Genome-Wide Association Studies (GWAS). This system makes it possible to merge study data with HapMap
Faheem Mitha   +5 more
doaj   +1 more source

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