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Genome-Wide Association Study of Motor Coordination [PDF]
Frontiers in Human Neuroscience, 2021 The ability to finely control our movement is key to achieving many of the educational milestones and life-skills we develop throughout our lives. Despite the centrality of coordination to early development, there is a vast gap in our understanding of the underlying biology.
Mountford, HS +3 more
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Genome-Wide Association Studies of Cancer [PDF]
Journal of Clinical Oncology, 2010 Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies.
Zsofia K, Stadler +9 more
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Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies. [PDF]
PLoS ONE, 2015 Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants.
Yongkang Kim, Taesung Park
doaj +1 more source
Replication in Genome-Wide Association Studies
Statistical Science, 2009 Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss prerequisites for exact replication, issues of heterogeneity, advantages and disadvantages of different methods of data ...
Kraft, Peter +2 more
openaire +6 more sources
BMC Bioinformatics, 2012 Background Genome-wide association studies (GWAS) with metabolic traits and metabolome-wide association studies (MWAS) with traits of biomedical relevance are powerful tools to identify the contribution of genetic, environmental and lifestyle factors to ...
Petersen Ann-Kristin +6 more
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Turning genome-wide association study findings into opportunities for drug repositioning
Computational and Structural Biotechnology Journal, 2020 Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much reduced cost.
Alexandria Lau, Hon-Cheong So
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Optimized homomorphic encryption solution for secure genome-wide association studies
BMC Medical Genomics, 2020 Background Genome-Wide Association Studies (GWAS) refer to observational studies of a genome-wide set of genetic variants across many individuals to see if any genetic variants are associated with a certain trait.
Marcelo Blatt +4 more
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SNP set association analysis for genome-wide association studies. [PDF]
PLoS ONE, 2013 Genome-wide association study (GWAS) is a promising approach for identifying common genetic variants of the diseases on the basis of millions of single nucleotide polymorphisms (SNPs).
Min Cai +9 more
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Genome-wide Association Studies
, 2013 Genome-wide association studies (GWAS) are a powerful hypothesis-free tool for the dissection of susceptibility to common heritable human diseases, including osteoporosis. To date, more than 2000 loci for common human diseases have been identified by GWAS.
Duncan, Emma, Brown, Matthew
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SNPpy--database management for SNP data from genome wide association studies. [PDF]
PLoS ONE, 2011 We describe SNPpy, a hybrid script database system using the Python SQLAlchemy library coupled with the PostgreSQL database to manage genotype data from Genome-Wide Association Studies (GWAS). This system makes it possible to merge study data with HapMap
Faheem Mitha +5 more
doaj +1 more source