Results 21 to 30 of about 1,107,991 (320)
Performance of epistasis detection methods in semi-simulated GWAS
BMC Bioinformatics, 2018 Background Part of the missing heritability in Genome Wide Association Studies (GWAS) is expected to be explained by interactions between genetic variants, also called epistasis. Various statistical methods have been developed to detect epistasis in case-
Clément Chatelain +3 more
doaj +1 more source
Methodological Issues in Multistage Genome-Wide Association Studies [PDF]
, 2009 Because of the high cost of commercial genotyping chip technologies, many investigations have used a two-stage design for genome-wide association studies, using part of the sample for an initial discovery of ``promising'' SNPs at a less stringent ...
Casey, Graham +5 more
core +1 more source
PLoS Genetics, 2009 Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new reference panels (such as controls genotyped on multiple SNP ...
Bryan N. Howie, P. Donnelly, J. Marchini
semanticscholar +1 more source
An Analysis Pipeline for Genome-wide Association Studies
Cancer Informatics, 2008 We developed an efficient pipeline to analyze genome-wide association study single nucleotide polymorphism scan results. Perl scripts were used to convert genotypes called using the BRLMM algorithm into a modified PB format.
Stefan Stefanov +2 more
doaj +2 more sources
Genome-wide Association Studies
, 2013 Genome-wide association studies (GWAS) are a powerful hypothesis-free tool for the dissection of susceptibility to common heritable human diseases, including osteoporosis. To date, more than 10,000 loci for common human diseases and traits have been identified by GWAS; and it is hard to think of a methodological breakthrough in recent times that has ...
Duncan, Emma, Brown, Matthew
openaire +4 more sources
Genome-wide association studies in ADHD [PDF]
, 2014 Attention-deficit/hyperactivity disorder, ADHD, is a common and highly heritable neuropsychiatric disorder that is seen in children and adults. Although heritability is estimated at around 76%, it has been hard to find genes underlying the disorder. ADHD
Faraone, Stephen V. +2 more
core +1 more source
Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies. [PDF]
PLoS ONE, 2015 Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants.
Yongkang Kim, Taesung Park
doaj +1 more source
The Role of Family-Based Designs in Genome-Wide Association Studies [PDF]
, 2009 Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs.
Laird, Nan M., Lange, Christoph
core +1 more source
Variance component model to account for sample structure in genome-wide association studies
Nature Genetics, 2010 Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test statistics and possibly spurious ...
H. Kang +7 more
semanticscholar +1 more source
Genome-wide association studies of the self-rating of effects of ethanol (SRE). [PDF]
, 2020 The level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for
Agrawal, Arpana +23 more
core +2 more sources