Results 21 to 30 of about 430,711 (260)

Genome-wide Association Study for AKI

Kidney360, 2023
Key Points Two genetic variants in the DISP1-TLR5 gene locus were associated with risk of AKI.DISP1 and TLR5 were differentially regulated in kidney biopsy tissue from patients with AKI compared with no AKI. Background
Pavan K. Bhatraju, Ian B. Stanaway, Melody R. Palmer, Rajasree Menon, Jennifer A. Schaub, Steven Menez, Anand Srivastava, F. Perry Wilson, Krzysztof Kiryluk, Paul M. Palevsky, Abhijit S. Naik, Sana S. Sakr, Gail P. Jarvik, Chirag R. Parikh, Lorraine B. Ware, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Steve G. Coca, Amit X. Garg, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Mark M. Wurfel   +24 more
openaire   +2 more sources

Genome-Wide Association Study of Motor Coordination [PDF]

Frontiers in Human Neuroscience, 2021
The ability to finely control our movement is key to achieving many of the educational milestones and life-skills we develop throughout our lives. Despite the centrality of coordination to early development, there is a vast gap in our understanding of the underlying biology.
Mountford, HS, Hill, A, Barnett, AL, Newbury, DF   +3 more
openaire   +7 more sources

Replication in Genome-Wide Association Studies

Statistical Science, 2009
Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss prerequisites for exact replication, issues of heterogeneity, advantages and disadvantages of different methods of data ...
Kraft, Peter, Zeggini, Eleftheria, Ioannidis, John P. A.   +2 more
openaire   +6 more sources

Genome-Wide Association Studies of Cancer [PDF]

Journal of Clinical Oncology, 2010
Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies.
Zsofia K, Stadler, Peter, Thom, Mark E, Robson, Jeffrey N, Weitzel, Noah D, Kauff, Karen E, Hurley, Vincent, Devlin, Bert, Gold, Robert J, Klein, Kenneth, Offit   +9 more
openaire   +2 more sources

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

BMC Bioinformatics, 2012
Background Genome-wide association studies (GWAS) with metabolic traits and metabolome-wide association studies (MWAS) with traits of biomedical relevance are powerful tools to identify the contribution of genetic, environmental and lifestyle factors to ...
Petersen Ann-Kristin, Krumsiek Jan, Wägele Brigitte, Theis Fabian J, Wichmann H-Erich, Gieger Christian, Suhre Karsten   +6 more
doaj   +1 more source

Turning genome-wide association study findings into opportunities for drug repositioning

Computational and Structural Biotechnology Journal, 2020
Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much reduced cost.
Alexandria Lau, Hon-Cheong So
doaj   +1 more source

SNP set association analysis for genome-wide association studies. [PDF]

PLoS ONE, 2013
Genome-wide association study (GWAS) is a promising approach for identifying common genetic variants of the diseases on the basis of millions of single nucleotide polymorphisms (SNPs).
Min Cai, Hui Dai, Yongyong Qiu, Yang Zhao, Ruyang Zhang, Minjie Chu, Juncheng Dai, Zhibin Hu, Hongbing Shen, Feng Chen   +9 more
doaj   +1 more source

Genome-Wide Association Studies in Glioma [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2018
Abstract Since the first reports in 2009, genome-wide association studies (GWAS) have been successful in identifying germline variants associated with glioma susceptibility. In this review, we describe a chronological history of glioma GWAS, culminating in the most recent study comprising 12,496 cases and 18,190 controls. We additionally
Kinnersley, B, Houlston, RS, Bondy, ML
openaire   +3 more sources

Optimized homomorphic encryption solution for secure genome-wide association studies

BMC Medical Genomics, 2020
Background Genome-Wide Association Studies (GWAS) refer to observational studies of a genome-wide set of genetic variants across many individuals to see if any genetic variants are associated with a certain trait.
Marcelo Blatt, Alexander Gusev, Yuriy Polyakov, Kurt Rohloff, Vinod Vaikuntanathan   +4 more
doaj   +1 more source

Genome-wide Association Studies

, 2013
Genome-wide association studies (GWAS) are a powerful hypothesis-free tool for the dissection of susceptibility to common heritable human diseases, including osteoporosis. To date, more than 2000 loci for common human diseases have been identified by GWAS.
Duncan, Emma, Brown, Matthew
openaire   +5 more sources