Genome-wide association studies of brain imaging phenotypes in UK Biobank
Nature, 2018 The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects)
L. Elliott +7 more
semanticscholar +3 more sources
Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity [PDF]
, 2020 There has been extensive discussion of the Replication Crisis in many fields, including genome-wide association studies
Cheng, Riyan +7 more
core +2 more sources
Genome Medicine, 2022 Background Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic ancestry and social determinants of health.
Ruth Johnson +25 more
doaj +1 more source
H3AGWAS: a portable workflow for genome wide association studies
BMC Bioinformatics, 2022 Background Genome-wide association studies (GWAS) are a powerful method to detect associations between variants and phenotypes. A GWAS requires several complex computations with large data sets, and many steps may need to be repeated with varying ...
Jean-Tristan Brandenburg +6 more
doaj +1 more source
Revealing the molecular signatures of host-pathogen interactions. [PDF]
, 2011 Advances in sequencing technology and genome-wide association studies are now revealing the complex interactions between hosts and pathogen through genomic variation signatures, which arise from evolutionary co ...
C Herdtweck +53 more
core +17 more sources
A concise history of genome-wide association studies
Saudi Journal of Medicine and Medical Sciences, 2013 Genome-wide association studies (GWASs) have had a tremendous impact on the pace of genomic research of common diseases. The number of identified genetic variants associated has grown exponentially. For some diseases, such as coronary heart disease (CHD),
Bobby P. C. Koeleman +3 more
doaj +1 more source
The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change. [PDF]
, 2020 In pharmacogenomic studies of quantitative change, any association between genetic variants and the pretreatment (baseline) measurement can bias the estimate of effect between those variants and drug response.
Haldar, Tanushree +8 more
core +2 more sources
Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts [PDF]
Genomics & Informatics, 2014 Metabolic syndrome (MetS) is a complex disorder related to insulin resistance, obesity, and inflammation. Genetic and environmental factors also contribute to the development of MetS, and through genome-wide association studies (GWASs), important ...
Unjin Shim +3 more
doaj +1 more source
Meta-Analysis of Genome-Wide Linkage Studies in Celiac Disease. [PDF]
, 2009 OBJECTIVE: A meta-analysis of genome-wide linkage studies allows us to summarize the extensive information available from family-based studies, as the field moves into genome-wide association studies. METHODS: Here we apply the genome scan meta-analysis
Babron MC +9 more
core +1 more source
Nucleic Acids Res., 2018 The GWAS Catalog delivers a high-quality curated collection of all published genome-wide association studies enabling investigations to identify causal variants, understand disease mechanisms, and establish targets for novel therapies.
A. Buniello +23 more
semanticscholar +1 more source