Results 11 to 20 of about 22,469,227 (260)

Genome-Wide Association Studies of the PR Interval in African Americans [PDF]

open access: yes, 2011
The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races.
Paltoo, Dina N.   +181 more
core   +1 more source

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process [PDF]

open access: yes, 2014
Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of ...
Springelkamp, H   +667 more
core   +6 more sources

Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned [PDF]

open access: yes, 2010
Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imputed single-nucleotide polymorphisms (SNPs)).
D I Boomsma   +145 more
core   +2 more sources

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA [PDF]

open access: yes, 2012
Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.
Palmer Cameron D.   +353 more
core   +3 more sources

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins [PDF]

open access: yes, 2014
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.
Herrington, D.M.   +627 more
core   +2 more sources

Genome-wide association study of receptive language ability of 12 year olds [PDF]

open access: yes, 2013
Purpose: We have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. The current study attempted to identify some of the genes responsible for the heritability of receptive language ...
Hanscombe, K.B.   +32 more
core   +1 more source

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. [PDF]

open access: yes, 2011
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA.
Keating, BJ   +999 more
core   +2 more sources

Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies. [PDF]

open access: yesPLoS ONE, 2015
Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants.
Yongkang Kim, Taesung Park
doaj   +1 more source

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits [PDF]

open access: yes, 2011
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis ...
Palmer Cameron D.   +803 more
core   +5 more sources

Chapter 11: Genome-wide association studies.

open access: yesPLoS Computational Biology, 2012
Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease.
William S Bush, Jason H Moore
doaj   +1 more source

Home - About - Disclaimer - Privacy