Results 221 to 230 of about 560,868 (267)

Investigation of risk factors for osteoporosis with a focus on hypertension and estimation of the causal effect of hypertension on osteoporosis using causal forest. [PDF]

Hypertens Res
Uematsu T, Nojiri S, Urasaki W, Nishizaki Y.   +3 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The causal effect of multiple lifestyles and myopia: a Mendelian randomization study. [PDF]

Sci Rep
Su MR, Zou X, Xie HR, Li YS, Wang XF, Sun XH, Jiang F.   +6 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Causal Effect of Pulmonary Hypertension on Brain Structure: A Mendelian Randomization Study Combined With Brain Magnetic Resonance Imaging. [PDF]

Cureus
Liu A, Wang H, Xi L, Du J, Wang J, Ni Y, Zhang S, Zhang P, Liu M.   +8 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The Causal Effect of Gun Violence on Everyday Mobility Patterns Across US Neighborhoods. [PDF]

Spat Demogr
Vachuska K, Movahed M.
europepmc   +1 more source

The Causal Effect of Foreign Exchange Intervention Disclosure: Evidence from Japan's Return to Active Intervention

Zhenkun Lu, Keigo Kameda, Genki Urushidani   +2 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Deciphering the causal effect of metabolic syndrome and its components on pruritus: Evidence from Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zeng A, Chen J, Yu Y, Hu J, Zhao S, Wu W.   +5 more
europepmc   +1 more source