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The Causal Effects of Father Absence [PDF]

Annual Review of Sociology, 2013
The literature on father absence is frequently criticized for its use of cross-sectional data and methods that fail to take account of possible omitted variable bias and reverse causality. We review studies that have responded to this critique by employing a variety of innovative research designs to identify the causal effect of father absence ...
Laura Tach, Sara McLanahan, Daniel Schneider   +2 more
openaire   +3 more sources

Bayesian causal discovery for policy decision making

Data & Policy
This paper demonstrates how learning the structure of a Bayesian network, often used to predict and represent causal pathways, can be used to inform policy decision-making.
Catarina Moreira, Ngoc Lan Chi Nguyen, Gilad Francis, Hadi Mohasel Afshar, Anna Lopatnikova, Sally Cripps, Roman Marchant   +6 more
doaj   +1 more source

Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study

Frontiers in Neuroscience, 2023
IntroductionNumerous studies have suggested a connection between circadian rhythm and neurological disorders with cognitive and consciousness impairments in humans, yet little evidence stands for a causal relationship between circadian rhythm and the ...
Fan Yang, Fan Yang, Fan Yang, Fan Yang, Fan Yang, Ru Liu, Sheng He, Sheng He, Sijie Ruan, Binghua He, Junda Li, Linghui Pan, Linghui Pan, Linghui Pan, Linghui Pan   +14 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Mendelian randomization study reveals a causal relationship between coronary artery disease and cognitive impairment

Frontiers in Cardiovascular Medicine, 2023
BackgroundGrowing evidence suggests that Coronary artery disease (CAD) is associated with cognitive impairment. However, these results from observational studies was not entirely consistent, with some detecting no such association. And it is necessary to
Shihan Xu, Shihan Xu, Yanfei Liu, Yanfei Liu, Qing Wang, Qing Wang, Fenglan Liu, Fengqin Xu, Fengqin Xu, Yue Liu   +9 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Assessment of causal associations among gut microbiota, metabolites, and celiac disease: a bidirectional Mendelian randomization study

Frontiers in Microbiology, 2023
BackgroundA growing number of studies have implicated that gut microbial abundance and metabolite concentration alterations are associated with celiac disease (CD). However, the causal relationship underlying these associations is unclear.
Ting Li, Yan Feng, Chun Wang, Tian Shi, Adilai Abudurexiti, Mengxia Zhang, Feng Gao, Feng Gao   +7 more
doaj   +1 more source

On the Representation of Causal Background Knowledge and its Applications in Causal Inference [PDF]

arXiv, 2022
Causal background knowledge about the existence or the absence of causal edges and paths is frequently encountered in observational studies. The shared directed edges and links of a subclass of Markov equivalent DAGs refined due to background knowledge can be represented by a causal maximally partially directed acyclic graph (MPDAG).
arxiv  

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study

Frontiers in Genetics, 2023
Objective: To elucidate the potential causality of leukocyte telomere length (LTL) with immune-mediated inflammatory diseases (IMIDs), we conducted a Mendelian randomization (MR) study.Methods: The genetically predicted causation between LTL and IMIDs ...
Meiling Liu, Ping Luo, Lihua Liu, Xianping Wei, Xue Bai, Jicui Li, Linlin Wu, Manyu Luo   +7 more
doaj   +1 more source