Results 31 to 40 of about 96,494 (250)

Estimating Mann–Whitney-Type Causal Effects for Right-Censored Survival Outcomes

Journal of Causal Inference, 2019
Mann–Whitney-type causal effects are clinically relevant, easy to interpret, and readily applicable to a wide range of study settings. This article considers estimation of such effects when the outcome variable is a survival time subject to right ...
Zhang Zhiwei, Liu Chunling, Ma Shujie, Zhang Min   +3 more
doaj   +1 more source

Real-Time Causal Inference

SSRN Electronic Journal, 2017
Engineers often need to understand how to deploy new innovations to maximize impact in real-time environments. For collaborations to succeed, researchers must understand and communicate statistical causal inference in ways that are consistent with unstructured settings where estimates can change in real-time.
openaire   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Estimating Causal Effects of New Treatments Despite Self-Selection: The Case of Experimental Medical Treatments

Journal of Causal Inference, 2019
Providing terminally ill patients with access to experimental treatments, as allowed by recent “right to try” laws and “expanded access” programs, poses a variety of ethical questions.
Hazlett Chad
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Testing for the Unconfoundedness Assumption Using an Instrumental Assumption

Journal of Causal Inference, 2014
The identification of average causal effects of a treatment in observational studies is typically based either on the unconfoundedness assumption (exogeneity of the treatment) or on the availability of an instrument.
de Luna Xavier, Johansson Per
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Effects of Neural Assembles in Causal Inference Based on an Entropy-Maximization Bayesian Neural Network

IEEE Access
Causal inference is an important function of the nervous system. To explore causal inference, Bayesian inference performs as the possible framework, mapping neural implementation onto various cortical areas.
Weisi Liu, Xiaogang Pan
doaj   +1 more source

Causality, a Trialogue

Journal of Causal Inference, 2014
A philosopher, a medical doctor, and a statistician talk about causality. They discuss the relationships between causality, chance, and statistics, resorting to examples from medicine to develop their arguments.
Chambaz Antoine, Drouet Isabelle, Thalabard Jean-Christophe   +2 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source