Results 51 to 60 of about 1,076,580 (347)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Interventional Approach for Path-Specific Effects

Journal of Causal Inference, 2017
Standard causal mediation analysis decomposes the total effect into a direct effect and an indirect effect in settings with only one single mediator.
Lin Sheng-Hsuan, VanderWeele Tyler
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A Kernel-Based Metric for Balance Assessment

Journal of Causal Inference, 2018
An important goal in causal inference is to achieve balance in the covariates among the treatment groups. In this article, we introduce the concept of distributional balance preserving which requires the distribution of the covariates to be the same in ...
Zhu Yeying, Savage Jennifer S., Ghosh Debashis   +2 more
doaj   +1 more source

The variance of causal effect estimators for binary v-structures

Journal of Causal Inference, 2022
Adjusting for covariates is a well-established method to estimate the total causal effect of an exposure variable on an outcome of interest. Depending on the causal structure of the mechanism under study, there may be different adjustment sets, equally ...
Kuipers Jack, Moffa Giusi
doaj   +1 more source

Causal Inference With Observational Data and Unobserved Confounding Variables

bioRxiv
Experiments have long been the gold standard for causal inference in Ecology. Observational data has been primarily used to validate experimental results or to find patterns that inspire experiments – not for causal inference.
Jarrett E. K. Byrnes, L. Dee
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Learning Heterogeneity in Causal Inference Using Sufficient Dimension Reduction

Journal of Causal Inference, 2019
Often the research interest in causal inference is on the regression causal effect, which is the mean difference in the potential outcomes conditional on the covariates. In this paper, we use sufficient dimension reduction to estimate a lower dimensional
Luo Wei, Wu Wenbo, Zhu Yeying
doaj   +1 more source

Identifying HIV sequences that escape antibody neutralization using random forests and collaborative targeted learning

Journal of Causal Inference, 2022
Recent studies have indicated that it is possible to protect individuals from HIV infection using passive infusion of monoclonal antibodies. However, in order for monoclonal antibodies to confer robust protection, the antibodies must be capable of ...
Jin Yutong, Benkeser David
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source