Results 61 to 70 of about 133,258 (310)

The variance of causal effect estimators for binary v-structures

open access: yesJournal of Causal Inference, 2022
Adjusting for covariates is a well-established method to estimate the total causal effect of an exposure variable on an outcome of interest. Depending on the causal structure of the mechanism under study, there may be different adjustment sets, equally ...
Kuipers Jack, Moffa Giusi
doaj   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara   +7 more
wiley   +1 more source

Causal reasoning and meta learning using kernel mean embeddings [PDF]

open access: yes, 2023
Kernel methods have been an essential instrument in machine learning over the years due to their ability to map data into high dimensional spaces efficiently.
Ton, Jean-Francois
core   +2 more sources

Sufficient Causes: On Oxygen, Matches, and Fires

open access: yesJournal of Causal Inference, 2019
We demonstrate how counterfactuals can be used to compute the probability that one event was/is a sufficient cause of another, and how counterfactuals emerge organically from basic scientific knowledge, rather than manipulative experiments.
Pearl Judea
doaj   +1 more source

Identifying HIV sequences that escape antibody neutralization using random forests and collaborative targeted learning

open access: yesJournal of Causal Inference, 2022
Recent studies have indicated that it is possible to protect individuals from HIV infection using passive infusion of monoclonal antibodies. However, in order for monoclonal antibodies to confer robust protection, the antibodies must be capable of ...
Jin Yutong, Benkeser David
doaj   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris   +24 more
wiley   +1 more source

Decision-theoretic foundations for statistical causality

open access: yesJournal of Causal Inference, 2021
We develop a mathematical and interpretative foundation for the enterprise of decision-theoretic (DT) statistical causality, which is a straightforward way of representing and addressing causal questions.
Dawid Philip
doaj   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier   +11 more
wiley   +1 more source

Nonparametric inference for interventional effects with multiple mediators

open access: yesJournal of Causal Inference, 2021
Understanding the pathways whereby an intervention has an effect on an outcome is a common scientific goal. A rich body of literature provides various decompositions of the total intervention effect into pathway-specific effects.
Benkeser David, Ran Jialu
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono   +7 more
wiley   +1 more source

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