Results 61 to 70 of about 917,002 (254)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Nonparametric inference for interventional effects with multiple mediators

open access: yesJournal of Causal Inference, 2021
Understanding the pathways whereby an intervention has an effect on an outcome is a common scientific goal. A rich body of literature provides various decompositions of the total intervention effect into pathway-specific effects.
Benkeser David, Ran Jialu
doaj   +1 more source

Causal Inference in Quantum Mechanics: A Reassessment [PDF]

open access: yes, 2007
There has been an intense discussion, albeit largely an implicit one, concerning the inference of causal hypotheses from statistical correlations in quantum mechanics ever since John Bell’s first statement of his notorious theorem in 1966.
Suárez, Mauricio
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Incremental intervention effects in studies with dropout and many timepoints#

open access: yesJournal of Causal Inference, 2021
Modern longitudinal studies collect feature data at many timepoints, often of the same order of sample size. Such studies are typically affected by dropout and positivity violations.
Kim Kwangho   +2 more
doaj   +1 more source

Causal Inference in the Multisensory Brain [PDF]

open access: yesNeuron, 2018
When combining information across different senses humans need to flexibly select cues of a common origin whilst avoiding distraction from irrelevant inputs. The brain could solve this challenge using a hierarchical principle, by deriving rapidly a fused sensory estimate for computational expediency and, later and if required, filtering out irrelevant ...
Cao, Yinan   +4 more
openaire   +3 more sources

Causal Inference in Comparative and International Education

open access: yes
All phenomena in the social sciences are shaped by a complex web of variables, and using data to detect patterns and trends in such variables is important.
Kameshwara, K., Gorman, E.
core   +4 more sources

Improving Outcomes in Machine Learning and Data-Driven Learning Systems using Structural Causal Models [PDF]

open access: yes, 2023
The field of causal inference has experienced rapid growth and development in recent years. Its significance in addressing a diverse array of problems and its relevance across various research and application domains are increasingly being acknowledged ...
Mbogu, Henry Maduka
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Revisiting a Discrepant Result: A Propensity Score Analysis, the Paired Availability Design for Historical Controls, and a Meta-Analysis of Randomized Trials

open access: yesJournal of Causal Inference, 2013
There is an ongoing controversy over whether epidural analgesia for women in labor increases the probability of Caesarean section. Previous research compared results from three methods for estimating the effect of epidural analgesia on the probability of
G. Baker Stuart, S. Lindeman Karen
doaj   +1 more source

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