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Strengthening Real‐World Evidence: Recognizing and Overcoming Methodological Pitfalls in Observational Health Data [PDF]
Learning Health SystemsIntroduction Real‐world health data (RWD), typically derived from electronic health records, administrative claims, patient registries, wearable devices, and other non‐experimental sources, are increasingly used to generate real‐world evidence (RWE) in ...
Daniel L. Gillen
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Ethical review of real-world study
Реальная клиническая практика: данные и доказательства, 2022 This article is devoted to an ethical review of planned real-world studies. The legal basis of such examinations has also been considered. Most real-world studies are non-interventional, so the ethical review of such studies is similar to that of ...
E. A. Volskaya +2 more
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Journal of Trial and Error, 2020 Alcohol and its effects on aggression have been the subject of many discussions and research papers. Despite this fact, there is still a debate surrounding what it is exactly about alcohol that causes aggression. The current study sought to replicate the
Kristel De Groot
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Sensitivity analysis for causal effects with generalized linear models
Journal of Causal Inference, 2022 Residual confounding is a common source of bias in observational studies. In this article, we build upon a series of sensitivity analyses methods for residual confounding developed by Brumback et al. and Chiba whose sensitivity parameters are constructed
Sjölander Arvid +2 more
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JCPP Advances, 2023 Background Prediction of mental disorders based on neuroimaging is an emerging area of research with promising first results in adults. However, research on the unique demographic of children is underrepresented and it is doubtful whether findings ...
Richard Gaus +4 more
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Journal of Causal Inference, 2022 Analysts often use data-driven approaches to supplement their knowledge when selecting covariates for effect estimation. Multiple variable selection procedures for causal effect estimation have been devised in recent years, but additional developments ...
Talbot Denis, Beaudoin Claudia
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Frontiers in Veterinary Science, 2020 Using sales data, information on antimicrobial consumption in animals is collected cumulatively across the European Union and member countries of the European Economic Area, which is documented and reported by every country and published within annual ...
Katharina Hommerich +4 more
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Administrative data in pediatric critical care research—Potential, challenges, and future directions
Frontiers in Pediatrics, 2022 Heterogenous patient populations with small case numbers constitute a relevant barrier to research in pediatric critical care. Prospective studies bring along logistic barriers and—if interventional—ethical concerns.
Nora Bruns +7 more
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Frontiers in Veterinary Science, 2022 Clinical decisions in human and veterinary medicine should be based on the best available evidence. The results of primary research are an important component of that evidence base.
Jan M. Sargeant +2 more
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Why do so many trials of vitamin D supplementation fail?
Endocrine Connections, 2020 Our knowledge of vitamin D has come a long way since the 100 years it took for doctors to accept, between 1860 and 1890, that both sunlight and cod liver oil (a well-known folk remedy) cured and prevented rickets. Vitamins D2/D3 were discovered exactly a
Barbara J Boucher
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