Results 161 to 170 of about 353,766 (277)

Estimating the value of face coverings during the COVID-19 epidemic: a dynamic causal modelling study. [PDF]

BMJ Public Health
Bowie C, Costello A, Friston K.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Dynamic causal modelling in probabilistic programming languages. [PDF]

J R Soc Interface
Baldy N, Woodman M, Jirsa VK, Hashemi M.
europepmc   +1 more source

Spectral dynamic causal modelling in healthy women reveals brain connectivity changes along the menstrual cycle. [PDF]

Commun Biol, 2021
Hidalgo-Lopez E, Zeidman P, Harris T, Razi A, Pletzer B.   +4 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Effective immunity and second waves: a dynamic causal modelling study [PDF]

Wellcome Open Res, 2020
Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizeau J, Hulme OJ, Billig AJ, Litvak V, Price CJ, Moran RJ, Costello A, Pillay D, Lambert C.   +13 more
europepmc   +2 more sources

Glucose-lowering effects of physical activity in type 1 diabetes: A causal modelling and matched-pair analysis approach. [PDF]

Diabet Med
Pemberton JS, Russon CL, Pulsford RM, Metcalf BS, Cockcroft E, Allen MJ, Frohock AM, Andrews RC.   +7 more
europepmc   +1 more source

Dynamic Causal Modelling Highlights the Importance of Decreased Self-Inhibition of the Sensorimotor Cortex in Motor Fatigability

, 2023
Heimhofer C, Bächinger M, Lehner R, Frässle S, Balsters JH, Wenderoth N.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Neurophysiological Progression in Alzheimer's Disease: Insights From Dynamic Causal Modelling of Longitudinal Magnetoencephalography. [PDF]

Hum Brain Mapp
Jafarian A, Assem MK, Kocagoncu E, Lanskey JH, Fye H, Williams R, Quinn AJ, Pitt J, Raymont V, Lowe S, Singh KD, Woolrich M, Nobre AC, Henson RN, Friston KJ, Rowe JB.   +15 more
europepmc   +1 more source