Causal relationship between gut microbiota and adenomyosis: metagenomics sequencing and Mendelian randomization. [PDF]
Front Cell Infect MicrobiolTang C, Li B, Chen J, Liu X, She C.
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Causal Relationship Between Blood Proteome and Retinitis Pigmentosa: A Mendelian Randomization Study. [PDF]
Transl Vis Sci TechnolJia C, Ma T, Jia L.
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Causal relationship between intervertebral disc degeneration and neurological disorders: A Mendelian randomization study. [PDF]
Medicine (Baltimore)Cao X.
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Assessing the Causal Relationship between Chronic Obstructive Pulmonary Disease and Tuberculosis: A Mendelian Randomization Study [PDF]
Zhuo Wang,1,* Shuang Zhao,1,* Yiwu Zhou,2– 4 Yanqi He1 1Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Emergency Department, West China ...
Zhao S, He Y, Zhou Y, Wang Z
core
Bidirectional Mendelian randomization explores the causal relationship between arthritis and cerebral cortical volume. [PDF]
Medicine (Baltimore)Zhou Y +5 more
europepmc +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Causal Relationship of Obstructive Sleep Apnea with Bone Mineral Density and the Role of BMI [PDF]
Fei Xu,1 XiuRong Zhang,2 YinRong Zhang,1 WenHui Chen,3 ZiCong Liao1 1General Surgery Department, Zhongshan Boai Hospital, Zhongshan, Guangdong, 528400, People’s Republic of China; 2Breast Surgery Department, Zhongshan Boai Hospital, Zhongshan, Guangdong,
Liao Z, Zhang Y, Zhang X, Chen W, Xu F
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