Results 51 to 60 of about 760,101 (303)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Link Prediction in Dynamic Social Networks Combining Entropy, Causality, and a Graph Convolutional Network Model

Entropy
Link prediction is recognized as a crucial means to analyze dynamic social networks, revealing the principles of social relationship evolution. However, the complex topology and temporal evolution characteristics of dynamic social networks pose ...
Xiaoli Huang, Jingyu Li, Yumiao Yuan
doaj   +1 more source

Türkiye’de Tasarruf, Finansal Gelişmişlik ve Ekonomik Büyüme İlişkisi: Asimetrik Nedensellik Yaklaşımından Yeni Kanıtlar

Gaziantep Üniversitesi Sosyal Bilimler Dergisi, 2020
The purpose of this study is to analyze dynamic causal linkages among savings, financial development, and economic growth for Turkey’s economy. To this end, I benefit from the causality tests for time series analysis for the period 1980:q1-2015:q4.
Ahmet BAĞCI
doaj   +1 more source

Causality fields in nonlinear causal effect analysis

Frontiers of Information Technology & Electronic Engineering, 2022
与线性因果相比, 非线性因果具有更复杂的特点和内涵. 本文主要讨论非线性因果中的若干个问题, 并着重强调因果域的概念. 本文基于广泛应用的计算模型和方法, 围绕非线性因果分析与计算以及因果域的识别问题提出相应观点和建议, 并通过几个具体案例揭示非线性因果在处理复杂因果推断问题中的重要性和现实意义.
Aiguo Wang, Li Liu, Jiaoyun Yang, Lian Li   +3 more
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

From experimental, structural probability distributions to the theoretical causality analysis of molecular changes

Computer Assisted Methods in Engineering and Science, 2017
A brief overview of causality analysis (CA) methods applied to MD simulations data for model biomolec ular systems is presented. A CausalMD application for postprocessing of MD data was designed and implemented.
Paweł Daniluk, Maciej Dziubiński, Bogdan Lesyng, Marta Hallay-Suszek, Franciszek Rakowski, Łukasz Walewski   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exchange rate and oil price interactions in transition economies: Czech republic, Hungary and Poland [PDF]

, 2015
This study investigates causal dynamics between crude oil prices and exchange rates in Czech Republic, Poland and Hungary by employing monthly data from the beginning of flexible exchange regime in each country to December 2011.
Bayat, T., Kayhan, S., Nazlıoğlu, Şaban   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source