Results 61 to 70 of about 262,504 (266)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Multidimensional Drought Relationships in the Yangtze River Basin: Causality, Propagation Thresholds, and Drought Resistance Capacity

Agriculture
A clear grasp of the interconnections among various drought types forms the foundation for effective drought mitigation policy-making. However, current research on the propagation of groundwater drought (GD) remains relatively limited.
Tian Wang, Bo Shi, Linqi Li, Zhaoqiang Zhou, Yibo Ding   +4 more
doaj   +1 more source

Integrating Genetic and Gene Co-expression Analysis Identifies Gene Networks Involved in Alcohol and Stress Responses

Frontiers in Molecular Neuroscience, 2018
Although the link between stress and alcohol is well recognized, the underlying mechanisms of how they interplay at the molecular level remain unclear.
Jie Luo, Jie Luo, Pei Xu, Pei Xu, Peijian Cao, Hongjian Wan, Xiaonan Lv, Shengchun Xu, Gangjun Wang, Melloni N. Cook, Melloni N. Cook, Byron C. Jones, Lu Lu, Lu Lu, Xusheng Wang   +14 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

The Relationship between Environmental Performance of Firms and Stock Returns: An Analysis in the Energy Sector

Hitit Sosyal Bilimler Dergisi
Today, with climate change, firms' reports, environmental disclosures and environmental performances that demonstrate their sensitivity to the environment have begun to be accepted by stakeholders.
Seren Aydıngülü Sakalsız
doaj   +1 more source

Study on Delay Propagation Relations Among Airports Based on Transfer Entropy

IEEE Access, 2020
To understand the mechanism of delay propagation from the perspective of multiple airports, constructing delay propagation relation (DPR) networks among airports is a novel analysis method.
Yinhong Xiao, Yaoshuai Zhao, Ge Wu, Yizhen Jing   +3 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Relationship Between Transfer Expenditures and Income Inequality: A Comparative Evaluation via Panel Causality Analysis

İzmir İktisat Dergisi, 2020
Bu çalışmada farklı gelişmişlik düzeyine sahip olan 39 ülkede transfer harcamaları ile gelir eşitsizliği arasındaki ilişkinin tespit edilmesi ve bu ilişkinin ülkelerin gelir eşitsizliği seviyesine göre farklılık gösterip göstermediğinin ortaya koyulması
Esra Doğan, Seher Gülşah Topuz
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source