Results 61 to 70 of about 26,118,825 (339)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Relationship Between Economic Growth and Foreign Aid: The Case of Afghanistan
İktisat Politikası Araştırmaları Dergisi, 2021 One of the main goals of foreign aid is to contribute to underdeveloped and developing countries’ economic growth and accelerate their growth. Foreign aid has been provided to Afghanistan by developed and developing countries for many years.
Muhammad Akbar Farahmand
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
EntropyLink prediction is recognized as a crucial means to analyze dynamic social networks, revealing the principles of social relationship evolution. However, the complex topology and temporal evolution characteristics of dynamic social networks pose ...
Xiaoli Huang, Jingyu Li, Yumiao Yuan
doaj +1 more source
Causality fields in nonlinear causal effect analysis
Frontiers of Information Technology & Electronic Engineering, 2022 与线性因果相比, 非线性因果具有更复杂的特点和内涵. 本文主要讨论非线性因果中的若干个问题, 并着重强调因果域的概念. 本文基于广泛应用的计算模型和方法, 围绕非线性因果分析与计算以及因果域的识别问题提出相应观点和建议, 并通过几个具体案例揭示非线性因果在处理复杂因果推断问题中的重要性和现实意义.
Aiguo Wang +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Gaziantep Üniversitesi Sosyal Bilimler Dergisi, 2020 The purpose of this study is to analyze dynamic causal linkages among savings, financial development, and economic growth for Turkey’s economy. To this end, I benefit from the causality tests for time series analysis for the period 1980:q1-2015:q4.
Ahmet BAĞCI
doaj +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source