Results 81 to 90 of about 26,118,825 (339)

Unraveling the Nexus between Road Transport Infrastructures and Economic Growth: Empirical Insights from Nepal’s Case

Economies
Sustained efforts and investments in different sectors are essential for the overall development of a region. Various studies around the globe underscore the importance of investment in road transport infrastructure in many developing countries to ...
Keshab Kumar Sharma, Netra Prakash Bhandary, Mandip Subedi, Rojee Pradhananga   +3 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Frequency decomposition of conditional Granger causality and application to multivariate neural field potential data

, 2006
It is often useful in multivariate time series analysis to determine statistical causal relations between different time series. Granger causality is a fundamental measure for this purpose.
Bressler, Steven L., Chen, Yonghong, Ding, Mingzhou   +2 more
core   +1 more source

Multiscale Granger causality analysis by \`a trous wavelet transform

, 2017
Since interactions in neural systems occur across multiple temporal scales, it is likely that information flow will exhibit a multiscale structure, thus requiring a multiscale generalization of classical temporal precedence causality analysis like ...
Bassez, Iege, Faes, Luca, Marinazzo, Daniele, Stramaglia, Sebastiano   +3 more
core   +1 more source

A failed top-down control from the prefrontal cortex to the amygdala in generalized anxiety disorder: Evidence from resting-state fMRI with Granger causality analysis.

Neuroscience Letters, 2019
In generalized anxiety disorder (GAD), abnormal top-down control from the prefrontal cortex (PFC) to the amygdala is a widely accepted hypothesis through which an "emotional dysregulation model" may be explained. However, whether and how the PFC directly
M. Dong, L. Xia, Min Lu, Chao Li, Ke Xu, Lina Zhang   +5 more
semanticscholar   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Multidimensional Drought Relationships in the Yangtze River Basin: Causality, Propagation Thresholds, and Drought Resistance Capacity

Agriculture
A clear grasp of the interconnections among various drought types forms the foundation for effective drought mitigation policy-making. However, current research on the propagation of groundwater drought (GD) remains relatively limited.
Tian Wang, Bo Shi, Linqi Li, Zhaoqiang Zhou, Yibo Ding   +4 more
doaj   +1 more source

Integrating Genetic and Gene Co-expression Analysis Identifies Gene Networks Involved in Alcohol and Stress Responses

Frontiers in Molecular Neuroscience, 2018
Although the link between stress and alcohol is well recognized, the underlying mechanisms of how they interplay at the molecular level remain unclear.
Jie Luo, Jie Luo, Pei Xu, Pei Xu, Peijian Cao, Hongjian Wan, Xiaonan Lv, Shengchun Xu, Gangjun Wang, Melloni N. Cook, Melloni N. Cook, Byron C. Jones, Lu Lu, Lu Lu, Xusheng Wang   +14 more
doaj   +1 more source

On the dynamics of energy consumption and employment in public and private sector. [PDF]

This study intended to analyze the direction of Granger-causality between energy consumption and employment in public and private sector. We have adopted DL approach for Granger-causality analysis.
Tiwari, Aviral
core   +1 more source