Results 211 to 220 of about 14,524,943 (303)

Impact of systemic immune-inflammation index and systemic inflammation response index on all-cause and cause-specific mortality: a community-based cohort study. [PDF]

Front Med (Lausanne)
Ke J, Wu K, Liu X, Qiu H, Liu Q, Song J, Liu Y, Ruan X, Zhou Y.   +8 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Association of red blood cell distribution width-to-albumin ratio with all-cause and cardiovascular mortality in adults with hyperuricemia: A cohort study from NHANES 1999 to 2018. [PDF]

Medicine (Baltimore)
Li J, Huang Y, Li C, Xun Q.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Mortality Among Youth and Young Adults With Autism Spectrum Disorder, Intellectual Disability, or Cerebral Palsy. [PDF]

JAMA Pediatr
Shaw KA, McArthur D, Bilder DA, Hughes MM, Rose CE, Bakian AV, Durkin MS, Fitzgerald RT, Howerton EM, Ladd-Acosta C, Lopez M, Pas ET, Zahorodny W, DiRienzo M, Patrick ME, Warren Z, Washington A, Hudson A, Pettygrove S, Shenouda J, Maenner MJ.   +20 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The combined predictive value of the triglyceride-glucose index and A Body Shape Index on all-cause mortality: a 26-year prospective cohort analysis from the Rancho Bernardo Study. [PDF]

Cardiovasc Diabetol Endocrinol Rep
Gerges Z, Ramkumar A, Hossain MI, Tee SS.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Hepatocellular Carcinoma Survival in People With and Without HIV in the United States, 2001-2019. [PDF]

Clin Infect Dis
McGee-Avila JK, Haas CB, Shing JZ, Lawrence WR, Joe NS, Pfeiffer RM, Luo Q, Hsieh MC, Cherala S, Pawlish KS, Monterosso A, Cohen C, Hayes J, Callaway BS, Drezner K, Engels EA, Shiels MS.   +16 more
europepmc   +1 more source