Results 231 to 240 of about 14,524,943 (303)

Causes justes, causes célèbres

, 2001
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

All-cause and cause-specific mortality trends among people with and without HIV in the Siaya health and demographic surveillance system, Kenya, 2011-2018. [PDF]

Glob Health Action
Ambia J, Trickey A, Ingle SM, Risher K, Odongo F, Reniers G, Kwaro D.   +6 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Impact of seasonal temperature variations on adverse outcomes in atrial fibrillation: comparative insights from Vigo and Murcia cohorts. [PDF]

J Glob Health
Soler-Espejo E, Ramos-Bratos MP, González-Bermúdez I, Rivera-Caravaca JM, Domínguez-Erquicia P, Íñiguez-Romo A, Marín F, Roldán V, Raposeiras-Roubín S.   +8 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Correction: Trends in mortality of the WHO-recommended diseases for palliative care in the Republic of Korea, 2014-2023. [PDF]

Front Public Health
Kim M, Kim K, Kim W, Nam EJ, Kye SY, Choi JY.   +5 more
europepmc   +1 more source

Surgical Versus Transcatheter Aortic Valve Replacement in Patients Aged >60 Years With Bicuspid Valve Stenosis: A Time-to-Event Data Meta-Analysis. [PDF]

J Am Heart Assoc
Moscarelli M, Lancellotti P, Athanasiou T, Casula R, Pernice V, Zaccone G, Nguyen Trung ML, Giannini F, Speziale G, Gaudino M, Fattouch K.   +10 more
europepmc   +1 more source

Remnant Cholesterol Inflammatory Index and Its Association With All-Cause Mortality Among General Population and Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From Two Nationwide Studies. [PDF]

Clin Cardiol
Ou CZ, Liu ZQ, Xiong YJ, Chen S, Lv T, Lou J.   +5 more
europepmc   +1 more source

Development of a national root cause analysis system for post-endoscopy upper gastrointestinal cancer. [PDF]

Endosc Int Open
Srinivasa A, Fiadeiro R, Gentry T, Goel S, Rahman T, Clements K, Chapman W, Burr N, Mukherjee D, Banks M, McCord M, Dhar A, Valori R, Trudgill N.   +13 more
europepmc   +1 more source