Results 61 to 70 of about 1,145,953 (258)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Retrospective analysis of mortality among children under 5 years of age in Huangshi over the period 2002–2022, China

BMC Public Health
Background The United Nations’ Millennium Development Goals and Sustainable Development Goals both underscore the critical need to reduce the under-five mortality rate globally.
Jumin Xie, Yihan Hong, Jianlin Yang, Yueming Yan, Shinuan Fei   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Natural, unnatural, and cause-specific mortality among current psychiatric inpatients: a systematic review and meta-analysisResearch in context

EClinicalMedicine
Summary: Background: Mortality in psychiatric hospitals is both elevated and poorly understood. We aimed to address a knowledge gap about cause-specific mortality among current psychiatric inpatients using a meta-analytic synthesis of primary research ...
Helena Angel-Scott, Ashna Basu, Allyson Tai, Pramudie Gunaratne, Patrick Bolton, Jackie Curtis, Grant Sara, Matthew Large   +7 more
doaj   +1 more source

Hospital-Based Mortality in Federal Capital Territory Hospitals-Nigeria, 2005- 2008

The Pan African Medical Journal, 2012
BACKGROUND: Cause-specific mortality data are important to monitor trends in mortality over time. Medical records provide reliable documentation of the causes of deaths occurring in hospitals.
Nykiconia Preacely, Oladayo Biya, Saheed Gidado, Halima Ayanleke, Mohammed Kida, Moses Akhimien, Aisha Abubakar, Ibrahim Kurmi, Ikeoluwapo Ajayi, Patrick Nguku, Henry Akpan   +10 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Results and observations from the reconstruction of continuous time series of mortality by cause of death: Case of West Germany, 1968-1997.

Demographic Research, 2009
Though many countries have been collecting cause-of-death information from death certificates for more than a century, these valuable data sources remain underexplored.
Marketa Pechholdova
doaj  

Validity of verbal autopsy method to determine causes of death among adults in the urban setting of Ethiopia

BMC Medical Research Methodology, 2012
Background Verbal autopsy has been widely used to estimate causes of death in settings with inadequate vital registries, but little is known about its validity.
Misganaw Awoke, Mariam Damen Haile, Araya Tekebash, Aneneh Aderaw   +3 more
doaj   +1 more source