Results 51 to 60 of about 47,971 (279)

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

SigmaFormer: Augmenting transformer encoders with COSMO sigma profiles for pure component property prediction

AIChE Journal, EarlyView.
Abstract Transformer‐based molecular models pretrained on SMILES strings demonstrate strong performance in property prediction. However, these model often lack explicit integration of molecular surface charge distributions that govern intermolecular interactions such as hydrogen bonding and polarity.
Tae Hyun Kim, Silabrata Pahari, Joseph Sang‐Il Kwon   +2 more
wiley   +1 more source

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Synthesis and Functional Properties of Fluorinated Phosphonate‐Substituted Porphyrins: Excellent Photosensitizers and Robust Precursors for Photoactive Langmuir–Schaefer Films

Chemistry – A European Journal, EarlyView.
This is a comprehensive study of new family of high functionalized meso‐tetraarylporphyrins. A synthetic approach to phosphonate‐substituted fluorinated porphyrins was developed. These compounds were investigated with respect to singlet oxygen generation and photostability.
Azhar Kechiche, Cyrille Monnereau, Chantal Andraud, Alla Bessmertnykh‐Lemeune, Yoann Rousselin, Andrey V. Cheprakov, Elizaveta V. Ermakova, Alexandra I. Zvyagina, Habib Nasri   +8 more
wiley   +1 more source

Cav-1 immunohistochemistry.

, 2013
A, C: Cav-1 staining on carotid plaques (red, 200x magnification). B: Endothelial staining (CD34, brown) on a consecutive section of A showing co-localization of Cav-1 and endothelium.
Frans L. Moll (50185), Theo van der Broek (50191), Gerard Pasterkamp (50194), Jean-Paul P. M. De Vries (50186), Joost Sluijter (50189), Evelyn Velema (50190), Juan A. Rodriguez-Feo (50183), Ben J. van Middelaar (50187), William C. Sessa (50192), Willem E. Hellings (50184), Ale Algra (50188), Dominique P. V. De Kleijn (50193)   +11 more
core   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

PSYNDEX Tests Review für CAV - Computer-Based Assessment of Visual Function

, 2017
This is a PSYNDEX Tests Review of CAV - Computer-Based Assessment of Visual Function. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries.
Schroth, Jennifer
core   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Software Verification for Weak Memory via Program Transformation [PDF]

, 2012
This version previously deposited at arXiv:1207.7264v1 [cs ...
Nimal, Vincent, Kroening, D, Tautschnig, Michael, Kroening, Daniel, Alglave, Jade, Alglave, J, Nimal, V, Tautschnig, M, Daniel Kroening, Vincent Nimal, Michael Tautschnig, Jade Alglave   +11 more
core   +1 more source

Comparison of Seismic Performance Assessment Using Observed or Simulated Ground Motions in Seismic Hazard Analysis and Ground Motion Selection

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This paper illustrates opportunities for the use of simulated ground motions in seismic performance assessment – from seismic hazard, ground‐motion selection, response history analysis, and seismic demand hazard calculation. The illustration is through a comparative analysis with the conventional alternative of observed ground motions.
Vahid Loghman, Brendon A. Bradley, Claudio Schill   +2 more
wiley   +1 more source