Results 161 to 170 of about 115,025 (287)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Microbial community succession along the entrance to distant zone in karst cave ecosystem: community assembly and distance decay patterns in weathered rock and sediment habitats. [PDF]

Environ Microbiome
Du J, Ma L, Huang X, Lu X, Wang H.
europepmc   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Using a Virtual Reality CAVE-Based Mindfulness Intervention to Promote Mental Well-Being in Adolescents With Anxiety Symptoms: Pre-Post Mixed Methods Pilot Study. [PDF]

JMIR Form Res
Yu CTK, Tsang APL, Chan KKY, Fung IOC, Ngai ZSY, Kwok LYC, Chan SKS, Fung GTF, Li SLS, Ching VWK, Kor PPK.   +10 more
europepmc   +1 more source

Heterointerface Engineering of Bismuth Nanosheets/Nitrogen‐Doped Carbon Nanoleaves Enables High‑Performance Electrochemical Dechlorination

Advanced Science, EarlyView.
Bismuth nanosheets integrated with nitrogen‐doped carbon nanoleaves are constructed via a 2D‐on‐2D heterointerface engineering strategy. The resulting BiNS/NCL electrode delivers high chloride adsorption capacity, fast kinetics, and stable cyclability. A built‐in electric field at the heterointerface promotes chloride electrosorption and stabilizes the
Bohan Liu, Feifei Pang, Xingtao Xu, Duo Yang, Xi Yu, Sikan Yang, Jiarui Hao, Nithima Khaorapapong, Zhichang Xiao, Xiaoxian Zhao, Yusuke Yamauchi, Shuaihua Zhang   +11 more
wiley   +1 more source

Cave microbial communities are structured by environmental matrix and depth and can be characterized with field-portable assays. [PDF]

Appl Environ Microbiol
Weingarten EA, Fernando BM, Freitas MR, Indest KJ.   +3 more
europepmc   +1 more source

A Crack‐Based One‐Dimensional Microspheres Array Enables Thermal–Mechanical Decoupled Dual‐Functional Sensing

Advanced Science, EarlyView.
Inspired by Nostoc, a crack‐based one‐dimensional microspheres array (COMA) sensor is developed, which stabilizes crack geometry under isotropic expansion, enabling a predictable, monotonic thermal response from which true strain can be accurately extracted. The COMA sensor exhibits high sensitivity at ultralow deformation (gauge factor up to 89) and a
Wanqing Xu, Hongyi Tu, Zehao Wang, Tianyu Zhu, Chao Wang, Min Chen, Lan Shi, Limin Wu   +7 more
wiley   +1 more source

Identity and mobility through personal ornaments in Upper Paleolithic cantabrian hunter-gatherer societies: Insights from Llonín cave (Asturias, Spain). [PDF]

PLoS One
Pérez-García de Los Salmones D, Cuenca-Solana D, González-Rabanal B, Marín-Arroyo AB, Duarte-Matías E, de la Rasilla-Vives M.   +5 more
europepmc   +1 more source

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

Habitat Specialization and Airborne Dispersal Shape the Microbiome of a Gypsum Karst Cave. [PDF]

Microb Ecol
Martin-Pozas T, Fernandez-Cortes A, Calaforra JM, Ledesma-Hernandez G, Cuezva S, Sanchez-Moral S, Saiz-Jimenez C, Jurado V.   +7 more
europepmc   +1 more source