Results 91 to 100 of about 12,285 (292)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Biology and ecology of the El Convento Cave-Spring System (Puerto Rico)

International Journal of Speleology, 1974
The El Convento Cave-Spring System is located at the head of the Quebrada de Los Cedros, approximately 20 km. west of Ponce, southwestern Puerto Rico. Although situated in an arid environment, the gorge receives sufficient moisture from the cave-spring system to support an abundant flora, with Bucida buceras and Bursera simaruba as the dominant trees ...
openaire   +3 more sources

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Biophysical Survey of the Hinatuan Enchanted River Underwater Cave System (HERUCS) and its Connecting River, Surigao del Sur, Southern Philippines

Annals of Tropical Research, 2016
A rapid survey inside the Hinatuan Enchanted River Underwater Cave System (HERUCS) and its connecting river was done to gather baseline data on the biophysical aspects of the cave and river ecosystem.
Ethel C. Wagas, Dave Anthony Valles, Cyril Taguba, Dominic Franco C. Belleza, Alex Santos, Bernil Gastardo, Terence Paul U. Dacles, Annie G. Diola, Danilo T. Dy   +8 more
doaj   +1 more source

Pholidota‐Inspired Electronic Skin Possessing Terahertz‐Wave Reflection–Absorption–Transmission Switchability

Advanced Science, EarlyView.
The pholidota‐inspired electronic skin is successfully constructed, originally realized four‐state reversible switching of terahertz‐wave reflection, absorption, transmission, and secondary reflection. In response to external demands, it issues deformation instructions, verifies the deformation state after the equipment executes the action, and thus ...
Shangjing Li, Jiangsong Hou, Yifeng Ruan, Jiang Du, Jun Qiu   +4 more
wiley   +1 more source

An Introduction to Gollum's Rule With an Assessment of Convergent Evolution among Cave-dwelling Malaysian Bent-toed Geckos

, 2019
Convergent evolution is a widely studied evolutionary phenomenon that has been documented in taxonomically diverse groups representing numerous ecosystems and specialized habitats. Yet one traditionally understudied system is the cave environment.
Cobos, Anthony
core  

Brain Transcriptomics Reveals Molecular Mechanisms of Cave Adaptation in Triplophysa Loaches

Ecology and Evolution
Understanding the adaptive evolution of brain function in extreme environments remains a central challenge in evolutionary biology. This study investigates the molecular mechanisms underlying cave adaptation by comparing brain transcriptomes of sympatric
Chunqing Li, Longting Wu, Fang Hu, Shanyuan Chen, Heng Xiao   +4 more
doaj   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Polystichum hastipinnum (subg. Haplopolystichum; Dryopteridaceae), a new cave fern from Guangdong, China

, 2017
A new species of Polystichum (subg. Haplopolystichum; Dryopteridaceae), P. hastipinnum, is described from a limestone cave in northern Guangdong, China. Polystichum hastipinnum is most similar to P.
Tang, GD, He, ZL, Zhang, LB (reprint author), Missouri Bot Garden, POB 299, St Louis, MO 63166 USA., Huang, L, Li, JY, Zhang, LB, Zhang, LB (reprint author), Chinese Acad Sci, Chengdu Inst Biol, POB 416, Chengdu 610041, Sichuan, Peoples R China.   +6 more
core   +1 more source