Results 111 to 120 of about 12,285 (292)

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Differentially-expressed opsin genes identified in Sinocyclo-cheilus cavefish endemic to China

Current Zoology, 2013
Eye degeneration is a common troglomorphic character of cave-dwelling organisms. Comparing the morphology and molecular biology of cave species and their close surface relatives is a powerful tool for studying regressive eye evolution and other adaptive ...
Fanwei MENG, Yahui ZHAO, John H. POSTLETHWAIT, Chunguang ZHANG
doaj  

Collaborative conservation of cave-roosting bats: guidance on managing rock climbing near caves

Frontiers in Conservation Science
Bats in North America have undergone unprecedented declines from various threats, including energy development, habitat loss, and disease. Mitigating these threats requires targeted conservation measures that address bat habitat and roosting requirements.
Robert A. Schorr, Zachary A. Warren, Katie Goodwin, Erik Murdock, Daniel J. Neubaum   +4 more
doaj   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Polystichum tiandengense (subg. Haplopolystichum; Dryopieridaceae), a New Cave Fern from Guangxi, China

, 2017
A new fern species, Polystichum tiandengense H. He & Li Bing Zhang (Dryopteridaceae), is described and illustrated from a limestone cave in the Guangxi Zhuangzu Autonomous Region, South China. Polystichum tiandengense is most similar to P.
He, H, Zhang, LB (reprint author), Missouri Bot Garden, POB 299, St Louis, MO 63166 USA., Zhang, LB, Zhang, LB (reprint author), Chinese Acad Sci, Chengdu Inst Biol, POB 416, Chengdu 610041, Sichuan, Peoples R China.   +3 more
core   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

The first emerging records of a dragonfly in the dark zone of subterranean ecosystems: Exuviae and newly emerged adults of Hyrcanian Goldenring, Cordulegaster vanbrinkae in Danial Cave, northern Iran

Ecology and Evolution
Riverine caves are special habitats that are home to many aquatic and terrestrial species. Some Odonata species and their emerging are recorded at the entrance and in the twilight zones of subterranean habitats around the world. However, the emergence of
Pouria Ghelich Khani, Mohsen Kiany, Ali Turk Qashqaei   +2 more
doaj   +1 more source

Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China

Advanced Science, EarlyView.
This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang, Yadong Yang, Yongsheng Wang, Guirui Yu   +3 more
wiley   +1 more source

Review The dark side of relict species biology: cave animals as ancient lineages

, 2010
Due to their fascinating biology and phenomena belonging to the realm of scientific curiosity, cave animals have been objects of study for zoologists for numerous decades.
Schuldt, Andreas, Habel, Jan Christian, Drees, Claudia, Casale, Achille, Matern, Andrea, Assmann, Thorsten   +5 more
core