Results 181 to 190 of about 40,137 (231)

The Cannabinoid CB1 Receptor in Schizophrenia

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021
Converging lines of evidence from epidemiological, preclinical, and experimental studies indicate that the endocannabinoid system may be involved in the pathophysiology of schizophrenia and suggest that the cannabinoid CB1 receptor may be a potential therapeutic target.
Faith Borgan, Michelle Kokkinou, Oliver Howes   +2 more
openaire   +3 more sources

Assay of CB1 Receptor Binding

2022
Type-1 cannabinoid receptor (CB1), one of the main targets of endocannabinoids, plays a key role in several pathophysiological conditions that affect both the central nervous system and peripheral tissues. Today, its biochemical identification and pharmacological characterization, as well as the screening of thousands of novel ligands that might be ...
Gasperi V, Savini I, Catani MV
openaire   +3 more sources

The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940)

Behavioural Pharmacology, 2005
It is well established that Cannabis sativa can increase appetite, particularly for sweet and palatable foods. In laboratory animals, cannabinoid CB1 receptor antagonism decreases motivation for palatable foods, and most recently, the CB1 receptor antagonist SR141716A, or rimonabant (Acomplia), was reported to produce weight loss in obese human ...
S J, Ward, L A, Dykstra
openaire   +2 more sources

CB1 Cannabinoid Receptor Ligands

Mini-Reviews in Medicinal Chemistry, 2005
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications.
Ganesh A, Thakur, Spyros P, Nikas, Alexandros, Makriyannis   +2 more
openaire   +2 more sources

CB1

, 2018
Cb
Braker, Elizabeth, Goffredi, Shana, Chelsea Blankenchip (5237126), Dana Michels (5237174), Shana Goffredi (4219843), Blankenchip, Chelsea, Elizabeth Braker (5237177), Michels, Dana   +7 more
openaire   +2 more sources

Assay of CB1 Receptor Binding

2016
Type-1 cannabinoid receptor (CB1), one of the main targets of endocannabinoids, plays a key role in several pathophysiological conditions that affect both central nervous system and peripheral tissues. Today, its biochemical identification and pharmacological characterization, as well as the screening of thousands of novel ligands that might be useful ...
Catani, VM, GASPERI, VALERIA
openaire   +4 more sources

Rimonabant—A Selective CB1 Antagonist

Annals of Pharmacotherapy, 2005
OBJECTIVE: To review the pharmacology, pharmacokinetics, clinical efficacy, and safety of rimonabant, a new selective cannabinoid receptor antagonist. DATA SOURCES: Primary literature and review articles were obtained via a MEDLINE ...
Steven Thomas, Boyd, Brad Allen, Fremming   +1 more
openaire   +2 more sources

Aminopyrazine CB1 receptor inverse agonists

Bioorganic & Medicinal Chemistry Letters, 2008
A series of 5,6-diaryl-2-amino-pyrazines were prepared and found to have antagonist-like properties at the CB1 receptor. Subsequent SAR studies optimized both receptor potency and drug-like properties including solubility and Cytochrome-P450 inhibition potential.
David J, Wustrow, George D, Maynard, Jun, Yuan, He, Zhao, Jianmin, Mao, Qin, Guo, Mark, Kershaw, Jack, Hammer, Robbin M, Brodbeck, Kristen E, Near, Dan, Zhou, David S, Beers, Bertrand L, Chenard, James E, Krause, Alan J, Hutchison   +14 more
openaire   +2 more sources

Allosteric Modulation of the Cannabinoid CB1 Receptor

Molecular Pharmacology, 2005
We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide), Org 27759 (3-ethyl-5-fluoro-1H-indole-2-carboxylic acid [2-94-dimethylamino-phenyl)-ethyl]-amide), and Org 29647 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid (1-benzyl-pyrrolidin-3-yl)-amide, 2 ...
Martin R, Price, Gemma L, Baillie, Adèle, Thomas, Lesley A, Stevenson, Morag, Easson, Richard, Goodwin, Adèle, McLean, Lorraine, McIntosh, Gillian, Goodwin, Glenn, Walker, Paul, Westwood, Julia, Marrs, Fiona, Thomson, Phillip, Cowley, Arthur, Christopoulos, Roger G, Pertwee, Ruth A, Ross   +16 more
openaire   +2 more sources

The role of CB1 receptors in psychostimulant addiction

Addiction Biology, 2008
ABSTRACTRecent studies have implicated the endocannabinoid (eCB) system in the neuronal mechanisms underlying substance dependence. Here, we review results of studies using cannabinoid receptor subtype 1 (CB1) knockout mice as well as CB1 antagonists to elucidate the role of this neurotransmitter system in psychostimulant addiction. The overall picture
Wiskerke, J., Pattij, T., Schoffelmeer, A.N.M., de Vries, T.J.   +3 more
openaire   +5 more sources