Results 191 to 200 of about 40,137 (231)

Diaryl piperidines as CB1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2010
The syntheses and SAR investigations of novel CB(1) receptor antagonists based on a 1,2-diaryl piperidine core have been described. Optimization of this core afforded a compound with robust in vivo potency by reducing food intake in a mouse DIO model.
Jack D, Scott, Sarah W, Li, Hongwu, Wang, Yan, Xia, Charles L, Jayne, Michael W, Miller, Ruth A, Duffy, George C, Boykow, Timothy J, Kowalski, Brian D, Spar, Andrew W, Stamford, Samuel, Chackalamannil, Jean E, Lachowicz, William J, Greenlee   +13 more
openaire   +2 more sources

The role of the CB1 receptor in the regulation of sleep

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008
During the 1990s, transmembranal proteins in the central nervous system (CNS) that recognize the principal compound of marijuana, the delta-9-tetrahydrocannabinol (Delta9-THC) were described. The receptors were classified as central or peripheral, CB1 and CB2, respectively. To this date, it has been documented the presence in the CNS of specific lipids
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The role of CB1 in immune modulation by cannabinoids

Pharmacology & Therapeutics, 2013
There is clear evidence that CB(2), historically referred to as the peripheral cannabinoid receptor, mediates many of the immune modulatory effects of cannabinoids. However, cannabinoid receptors cannot be classified simply as central or peripheral since CB(2) has been shown to play a role in the central nervous system (CNS) and CB(1) mediates many ...
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Peripherally restricted CB1 receptor blockers

Bioorganic & Medicinal Chemistry Letters, 2013
Antagonists (inverse agonists) of the cannabinoid-1 (CB1) receptor showed promise as new therapies for controlling obesity and related metabolic function/liver disease. These agents, representing diverse chemical series, shared the property of brain penetration due to the initial belief that therapeutic benefit was mainly based on brain receptor ...
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Pharmacology of cannabinoid CB1 and CB2 receptors

Pharmacology & Therapeutics, 1997
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 receptors in certain peripheral tissues. The existence of endogenous cannabinoid receptor agonists has also been demonstrated.
openaire   +2 more sources

CB1-CB112

Giornale Italiano di Cardiologia, 2015
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Crystal Structure of the Human Cannabinoid Receptor CB1

Cell, 2016
Suwen Zhao, Qiang Zhao, Mengchen Pu
exaly  

Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission

Neuropsychopharmacology, 2012
Beat Lutz, Maria-Paz Viveros, Martin Purrio   +2 more
exaly  

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB 1 Cannabinoid Receptor Knockout Mice

Journal of Neurochemistry, 2000
Chris Breivogel, Vincenzo di Marzo, A M Zimmer   +2 more
exaly  

CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages

Cardiovascular Research, 2009
Ju-Hee Kang, Chan-Sik Park, Soon-Suk Kang   +2 more
exaly