Results 61 to 70 of about 25,158 (238)

Pharmacological activation of CB1 and D2 receptors in rats: predominant role of CB1 in the increase of alcohol relapse

, 2008
The classical dopamine D2 receptor has been widely studied in alcoholism. Recently, different studies have explored the role of the CB1 receptor in alcohol-related behavior. In alcohol addiction, relapse is one of the central features.
Brooks, R.D., López Moreno, José Antonio, Moreno-Sanz, G., Navarro, M., Alén Fariñas, Francisco, Isabel de Tena, A., López-Jimenez, A.   +6 more
core   +1 more source

Δ9‐Tetrahydrocannabinolic acid alleviates collagen‐induced arthritis: Role of PPARγ and CB1 receptors

, 2020
Background and Purpose: Δ9 -Tetrahydrocannabinolic acid (Δ9 -THCA-A), the precur sor of Δ9 -THC, is a non-psychotropic phytocannabinoid that shows PPARγ agonist activity.
Gómez Cañas, María, Palomares, Belén, Fernández Ruiz, José Javier, Gonzalo Consuegra, Claudia, Muñoz, Eduardo   +4 more
core   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system

, 2008
INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1)
Judith Harvey-White, Francesca Lolli, Farkas, I., Amin, F., Mirjam Christ-Crain, Kola, Blerina, Fekete, Csaba, George Kunos, Kola, B., Faisal Amin, A. B. Grossman, M. Korbonits, Blerina Kola, Liposits, Zsolt, G. Kunos, Ashley B Grossman, B. Kola, Amin, F, Gábor Wittmann, Kunos, George, Christ-Crain, M, Farkas, Imre, Lolli, F, Zsolt Liposits, Lolli, F., F. Amin, Farkas, I, Christ-Crain, M., Korbonits, M., I. Farkas, Grossman, AB, C. Fekete, Kola, B, Harvey-White, J., Wittmann, Gábor, Korbonits, Márta, G. Wittmann, Harvey-White, J, Fekete, C, Harvey-White, Judith, Márta Korbonits, Imre Farkas, Liposits, Z, Z. Liposits, Grossman, Ashley B., Ashley B. Grossman, Wittmann, G., Christ-Crain, Mirjam, Amin, Faisal, Lolli, Francesca, Liposits, Z., M. Christ Crain, J. Harvey White, Fekete, C., Korbonits, M, Kunos, G., Csaba Fekete, Grossman, A. B., Kunos, G, Wittmann, G   +59 more
core   +1 more source

A consensus roadmap for post‐traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials

Epilepsia, EarlyView.
Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier, Ilaria Lisi, Elaine K. O'Loughlin, Federico Moro, Edilberto Amorim, David L. Brody, Daniel J. Correa, Dominique Duncan, Pavel Klein, Firas H. Kobeissy, Wolfgang Löscher, Edward J. Needham, Asla Pitkänen, Mary Jo Pugh, Jack Somers, Annamaria Vezzani, Amy K. Wagner, Laura S. Lubbers, International Conference on PTE Attendees, Denes Agoston, Edilberto Amorim, Sneha Anand, Hibah Awwad, Ginevra Bayon, Naima Belhachemi, Akash Bera, Costanza Bertani, Guido Bertolini, David L. Brody, Serena Brusatori, Francesca Buffelli, Aurora Chiapperini, Mara Chioccola, Severn Churn, Daniel J. Correa, Ramon Diaz‐Arrastia, Chris Dulla, Dominique Duncan, Chiara Ferlito, Aristea Galanopoulou, Angela Galic, Heidi Matos Galicia, Bin Gu, William Haskins, Victoria Johnson, Nigel Jones, Lowie Joseph, Pavel Klein, Firas Kobaissy, Ilaria Lisi, David Loane, Luther Loose, Laura S. Lubbers, Wolfgang Löscher, Edoardo Mazzone, Melissa Miller, Federico Moro, Edward J. Needham, Irma Wati Ngadimon, Terence O’Brien, Elaine K. O’Loughlin, Asla Pitkanen, Mary Jo Pugh, Teresa Giovanna Ravizza, Giuseppe Remuzzi, Massimo Rizzi, Rossella Di Sapia, Tawfeeq Shekh‐Ahmad, Doug Smith, Jack Somers, Kevin Staley, Francesca Tribuzio, Alexandra Ulyanova, Gloria Vegliante, Annamaria Vezzani, Joost Wagenaar, Amy K. Wagner, Kevin W. Wang, Justin Weppner, Peter J. West, Karen Wilcox, John Wolf, Elisa R. Zanier   +82 more
wiley   +1 more source

Off-target pharmacological profiling of synthetic cannabinoid receptor agonists including AMB-FUBINACA, CUMYL-PINACA, PB-22, and XLR-11

Frontiers in Psychiatry, 2022
IntroductionSynthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances that have been associated with multiple instances and types of toxicity. Some SCRAs appear to carry a greater toxicological burden than others,
Richard C. Kevin, Richard C. Kevin, Elizabeth A. Cairns, Elizabeth A. Cairns, Rochelle Boyd, Rochelle Boyd, Jonathon C. Arnold, Jonathon C. Arnold, Michael T. Bowen, Michael T. Bowen, Iain S. McGregor, Iain S. McGregor, Samuel D. Banister, Samuel D. Banister   +13 more
doaj   +1 more source

Efeitos do antagonismo de receptores CB1 sobre a consolidação da memória de medo contextual em diferentes períodos do ritmo circadiano [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.O ritmo circadiano sincroniza as fases inativa e ativa do organismo com a luminosidade do ...
Silva, Rafael Scoz
core  

Endocannabinoid Release Modulates Electrical Coupling between CCK Cells Connected via Chemical and Electrical Synapses in CA1.

, 2011
Electrical coupling between some subclasses of interneurons is thought to promote coordinated firing that generates rhythmic synchronous activity in cortical regions.
Ali eAfia, Jonathan eIball, Afia B. Ali, Jonathan Iball, Iball, J, Ali, AB   +5 more
core   +1 more source

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold   +5 more
wiley   +1 more source

Cannabinoid Modulation of Excitability and Short-Term Neuronal Dynamics in the Dorsal and Ventral Hippocampus

Biology
Endocannabinoids, acting primarily through CB1 receptors, are critical modulators of neuronal activity, influencing cognitive functions and emotional processing.
Giota Tsotsokou, Ioanna-Maria Sotiropoulou, Klearchos Stampolitis, George D. Oikonomou, Aikaterini-Paraskevi Avdi, Costas Papatheodoropoulos   +5 more
doaj   +1 more source