Results 81 to 90 of about 25,158 (238)

Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system. [PDF]

PLoS ONE, 2017
The endocannabinoid system is a regulatory pathway consisting of two main types of cannabinoid receptors (CB1 and CB2) and their endogenous ligands, the endocannabinoids. The CB1 receptor is highly expressed in the central and peripheral nervous systems (
Jessica Freundt-Revilla, Kristel Kegler, Wolfgang Baumgärtner, Andrea Tipold   +3 more
doaj   +1 more source

Intravenous paracetamol does not have significant opioid‐sparing effects when used as part of a multimodal analgesic protocol in dogs undergoing elective orthopaedic surgery

Veterinary Record, EarlyView.
Abstract Background Data evaluating paracetamol combined with NSAIDs in dogs are scarce. Results of clinical studies in dogs investigating intravenous paracetamol vary. Methods Dogs were randomised to either receive 10 mg/kg paracetamol intravenously after induction of anaesthesia and every 8 hours during hospitalisation (test) or not (control).
Robin Stallard, Julia Deutsch, Joanna Murrell   +2 more
wiley   +1 more source

Cannabinoid regulation of sex-dependent murine odorant-stimulated salivation

Scientific Reports
Salivation is easily taken for granted, but without normal salivation, simple essential tasks such as chewing and swallowing become difficult, with consequences for quality of life, nutrition and oral health.
Natalia Murataeva, Sam Mattox, Josh Lemieux, John Griffis, Kyle Yust, Wenwen Du, Thomas Heinbockel, Alex Straiker   +7 more
doaj   +1 more source

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

Remote Ischemia Preconditioning Attenuates Blood-Spinal Cord Barrier Breakdown in Rats Undergoing Spinal Cord Ischemia Reperfusion Injury: Associated with Activation and Upregulation of CB1 and CB2 Receptors

Cellular Physiology and Biochemistry, 2017
Background/Aims: Remote ischemic preconditioning (RIPC) has protective effects on spinal cord ischemia reperfusion (I/R) injury, but the potential mechanisms remain unclear. In our study, the effects and underlying mechanisms of RIPC on blood-spinal cord
Na Jing, Bo Fang, Zhi-Lin Wang, Hong Ma
doaj   +1 more source

Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration

British Journal of Clinical Pharmacology, EarlyView.
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.
Adrian A. Doerr, Christiane Dings, Omar Zaher, Frederike Nordmeier, Nadja Walle, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Markus R. Meyer, Thorsten Lehr, Nadine Schaefer   +10 more
wiley   +1 more source

Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55

Frontiers in Pharmacology, 2019
Background: Marijuana extracts (cannabinoids) have been used for several millennia for pain treatment. Regarding the site of action, cannabinoids are highly promiscuous molecules, but only two cannabinoid receptors (CB1 and CB2) have been deeply studied ...
Raquel Guerrero-Alba, Paulino Barragán-Iglesias, Abimael González-Hernández, Eduardo E. Valdez-Moráles, Vinicio Granados-Soto, Miguel Condés-Lara, Martín G. Rodríguez, Bruno A. Marichal-Cancino   +7 more
doaj   +1 more source

Peripherally acting CB1-receptor antagonist: the relative importance of central and peripheral CB1 receptors in adiposity control [PDF]

International Journal of Obesity, 2009
To investigate whether drugs targeting peripheral cannabinoid-1 (CB1) receptor ameliorate adiposity comparable to central CB1-receptor antagonist or not.Receptor binding assay and functional assay in vitro. Pharmacokinetic parameters in mice, brain uptake clearance of compounds in rats and antagonism on the CB1-agonist-induced hypothermia in mice. Diet
M-H, Son, H D, Kim, Y N, Chae, M-K, Kim, C Y, Shin, G J, Ahn, S-H, Choi, E K, Yang, K-J, Park, H W, Chae, H-S, Moon, S-H, Kim, Y-G, Shin, S-H, Yoon   +13 more
openaire   +2 more sources

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis

Neurobiology of Disease, 2005
Recent studies have addressed the changes in endocannabinoid ligands and receptors that occur in multiple sclerosis, as a way to explain the efficacy of cannabinoid compounds to alleviate spasticity, pain, tremor, and other signs of this autoimmune ...
Ana Cabranes, Katerina Venderova, Eva de Lago, Filomena Fezza, Antonio Sánchez, Leyre Mestre, Marta Valenti, Antonio García-Merino, José Antonio Ramos, Vincenzo Di Marzo, Javier Fernández-Ruiz   +10 more
doaj   +1 more source