Results 51 to 60 of about 644 (148)

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Nature Communications, 2017
CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB2 receptor agonists and antagonists, recommending three that appear most suitable ...
Marjolein Soethoudt, Uwe Grether, Jürgen Fingerle, Travis W. Grim, Filomena Fezza, Luciano de Petrocellis, Christoph Ullmer, Benno Rothenhäusler, Camille Perret, Noortje van Gils, David Finlay, Christa MacDonald, Andrea Chicca, Marianela Dalghi Gens, Jordyn Stuart, Henk de Vries, Nicolina Mastrangelo, Lizi Xia, Georgios Alachouzos, Marc P. Baggelaar, Andrea Martella, Elliot D. Mock, Hui Deng, Laura H. Heitman, Mark Connor, Vincenzo Di Marzo, Jürg Gertsch, Aron H. Lichtman, Mauro Maccarrone, Pal Pacher, Michelle Glass, Mario van der Stelt   +31 more
doaj   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

eLife, 2020
Cannabinoid CB2 receptor (CB2) agonists are potential analgesics void of psychotropic effects. Peripheral immune cells, neurons and glia express CB2; however, the involvement of CB2 from these cells in neuropathic pain remains unresolved.
David Cabañero, Angela Ramírez-López, Eva Drews, Anne Schmöle, David M Otte, Agnieszka Wawrzczak-Bargiela, Hector Huerga Encabo, Sami Kummer, Antonio Ferrer-Montiel, Ryszard Przewlocki, Andreas Zimmer, Rafael Maldonado   +11 more
doaj   +1 more source

Continued population recovery and high annual survival rates of White‐rumped Vultures in Nepal

Ibis, EarlyView.
Populations of Gyps vultures in South Asia underwent catastrophic declines caused by unintentional poisoning by the veterinary drug diclofenac. Since the drug was banned in 2006–2010, declines have halted across the region, including in Nepal. The present study updates population trends of G.
John W. Mallord, Ankit B. Joshi, Ishwari P. Chaudhary, Deelip C. Thakur, Ishana Thapa, Krishna P. Bhusal, Deu B. Rana, Bed Kumar Dhakal, Toby H. Galligan, Rhys E. Green   +9 more
wiley   +1 more source

Computational Characterization of Nabilone-Induced Disruption of the CB2-HER2 Receptor Complex in HER2+ Breast Cancer

Bioinformatics and Biology Insights
Human epidermal growth factor receptor 2-positive (HER2+) breast cancer, accounting for 15% to 20% of cases, is often resistant to treatment. Delta-9-tetrahydrocannabinol (THC) disrupts HER2-cannabinoid receptor (2CB2) receptor complexes and inhibits ...
Abbou Hanane, Zegrari Razana, Gaouzi Zainab, Festali Rihab, Chemao-Elfihri Mohammed Walid, Hakmi Mohammed, El Jaoudi Rachid   +6 more
doaj   +1 more source

Liver X Receptor α–Induced Cannabinoid Receptor 2 Inhibits Ubiquitin‐Specific Peptidase 4 Through miR‐27b, Protecting Hepatocytes From TGF‐β

Hepatology Communications, 2019
Liver X receptor‐alpha (LXRα) acts as a double‐edged sword in different biological situations. Given the elusive role of LXRα in hepatocyte viability, this study investigated whether LXRα protects hepatocytes from injurious stimuli and the underlying ...
Hong Min Wu, Tae Hyun Kim, Ayoung Kim, Ja Hyun Koo, Min Sung Joo, Sang Geon Kim   +5 more
doaj   +1 more source

Synthesis and Biological Evaluation of Thiophene-Based Cannabinoid Receptor Type 2 Radiotracers for PET Imaging

Frontiers in Neuroscience, 2016
Over the past two decades, our understanding of the endocannabinoid system has greatly improved due to the wealth of results obtained from exploratory studies. Currently, two cannabinoid receptor subtypes have been well characterized.
Ahmed Haider, Adrienne Müller Herde, Roger Slavik, Markus Weber, Claudia Mugnaini, Alessia Ligresti, Roger Schibli, Linjing Mu, Simon Mensah Ametamey   +8 more
doaj   +1 more source

Effectiveness of plasma‐enhanced chemical vapor film in surface treatments of resin‐matrix ceramics to preserve optical characteristics after different aging processes

Journal of Prosthodontics, EarlyView.
Abstract Purpose The aim of this study was to evaluate the surface roughness and optical characteristics of three ceramics with resin matrix for computer‐aided design and computer‐aided manufacturing, after different surface treatment protocols associated or not with the application of film deposition by plasma‐enhanced chemical vapor deposition (PECVD)
Victor Alves Nascimento, Kevin Henrique Cruz, Lorena Scaion Silva, João Pedro Justino de Oliveira de Limírio, Ana Beatriz de Souza Albergardi, Elidiane Cipriano Rangel, Aldiéris Alves Pesqueira   +6 more
wiley   +1 more source