Results 11 to 20 of about 3,492 (143)

CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes [PDF]

Blood Advances, 2021
CBFB-MYH11 transcripts and KIT mutations predict relapse in AML. High-risk CBFB-MYH11 transcripts are associated with distinct transcriptional landscapes and upregulation of early hematopoiesis ...
Benjamin J Huang, Richard Aplenc, Kohei Hagiwara   +2 more
exaly   +4 more sources

Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe

Hematology/Oncology and Stem Cell Therapy, 2021
Del(16q) is an uncommon cytogenetic abnormality that can occur in different types of myeloid neoplasms. A small number of cases with del(16q) have been reported.
Doaa F. Temerik, Walaa T. El-Mahdy, Ahmed Makboul Ahmed   +2 more
doaj   +2 more sources

A novel cryptic CBFB-MYH11 gene fusion present at birth leading to acute myeloid leukemia and allowing molecular monitoring for minimal residual disease

Human Pathology: Case Reports, 2018
Acute myeloid leukemia (AML) with the inv(16)/t(16;16) karyotype is associated with a favourable prognosis, showing longer periods of complete remission and high overall survival rates.
P.J. Poddighe, M.A. Veening, M.B. Mansur, A.H. Loonen, T.M. Westers, P.A. Merle, J.W. Wessels, V. de Haas, W.A. Kors, S.L. Bhola, M.J. Wondergem, A.M. Ford, G.J.L. Kaspers   +12 more
doaj   +2 more sources

De Novo Acute Myeloid Leukemia with Combined CBFB-MYH11 and BCR-ABL1 Gene Rearrangements: A Case Report and Review of Literature [PDF]

Case Reports in Hematology, 2020
Acute myeloid leukemia (AML) with inv(16)(p13.1q22) resulting in CBFB-MYH11 fusion is associated with a favorable prognosis. The presence of a KIT mutation modifies it to an intermediate prognosis.
Venkata Rakesh Sethapati, Ra’ed Jabr, Leyla Shune, Wissam El Atrouni, Patrick R. Gonzales, Wei Cui, Shivani Golem   +6 more
doaj   +2 more sources

Therapy-related acute myeloid leukemia with CBFB/MYH11 in a patient with ovarian cancer after exposure to chemotherapy

Indian Journal of Pathology and Microbiology, 2023
In patients with acute myeloid leukemia (AML), about 25%–35% of patients have a history of other hematological diseases, 10% of patients have a history of malignant tumors in other systems and have received cytotoxic treatment including chemotherapy and ...
Xinhong Yang, Qiuxia Liu, Rongjuan Zhang, Xiaofeng Yang, Lihong Wang, Zhihua Zhang, Yan Li, Li Lin   +7 more
doaj   +2 more sources

Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia-initiating CBFB::MYH11 oncofusion protein. [PDF]

J Clin Invest, 2023
Several canonical translocations produce oncofusion genes that can initiate acute myeloid leukemia (AML). Although each translocation is associated with unique features, the mechanisms responsible remain unclear.
Day RB, Hickman JA, Xu Z, Katerndahl CD, Ferraro F, Ramakrishnan SM, Erdmann-Gilmore P, Sprung RW, Mi Y, Townsend RR, Miller CA, Ley TJ.   +11 more
europepmc   +2 more sources

CBFβ-SMMHC–driven leukemogenesis requires enhanced RUNX1-DNA binding affinity in mice [PDF]

The Journal of Clinical Investigation
The leukemia fusion gene CBFB-MYH11 requires RUNX1 for leukemogenesis, but the underlying mechanism is unclear. By in vitro studies, we found that CBFβ-SMMHC, the chimeric protein encoded by CBFB-MYH11, could enhance the binding affinity between RUNX1 ...
Tao Zhen, Yaqiang Cao, Tongyi Dou, Yun Chen, Guadalupe Lopez, Ana Catarina Menezes, Xufeng Wu, John A. Hammer, Jun Cheng, Lisa Garrett, Stacie Anderson, Martha Kirby, Stephen Wincovitch, Bayu Sisay, Abdel G. Elkahloun, Di Wu, Lucio H. Castilla, Wei Yang, Jiansen Jiang, Keji Zhao, P. Paul Liu   +20 more
doaj   +2 more sources

CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia [PDF]

Journal of Clinical Investigation, 2020
Anthony Rongvaux, Jamie Stokke, Kelda Gardner   +2 more
exaly   +2 more sources

Cohesin haploinsufficiency is tolerated in Cbfb::MYH11-driven murine acute myeloid leukemia. [PDF]

Exp Hematol
Cohesin gene mutations occur in many malignancies, including acute myeloid leukemia (AML). Loss-of-function mutations in the four major cohesin complex genes (RAD21, SMC3, SMC1a, and STAG2) occur across most major genetic subtypes of AML but are notably ...
Conneely SE, Quezada A, Kurtz KJ, Zhang N, Fuente J, Mercer N, Rogers JH, Aguilar R, Medrano G, Goodell MA, Liu PP, Pati D, Rau RE.   +12 more
europepmc   +2 more sources

Genetic landscape of pediatric acute myeloid leukemia in Taiwan [PDF]

Scientific Reports
The international consensus classification or the World Health Organization classifications underrepresented driver alterations enriched in pediatric acute myeloid leukemia (AML). To address this, we retrospectively characterized the genomic landscape of
Zhongshan Cheng, Sung-Liang Yu, Chih-Hsiang Yu, Ti-Cheng Chang, Ya-Hsuan Chang, Shiann-Tarng Jou, Meng-Yao Lu, Kai-Hsin Lin, Hsiu-Hao Chang, Shu-Wei Chou, Ze-Shiang Lin, Chieh-Wen Kuo, Phooi-Theng Liew, Chia-Jui Du, Chien-Yu Lin, Yu-Ling Ni, Hsuan-Yu Chen, Dong-Tsamn Lin, Shu-Wha Lin, Gang Wu, Ching-Hon Pui, Yung-Li Yang   +21 more
doaj   +2 more sources