Results 31 to 40 of about 3,492 (143)

ASSOCIAÇÃO ENTRE PARÂMETROS IMUNOFENOTÍPICOS E ESTRATIFICAÇÃO DE RISCO EM PACIENTES PORTADORES DE LEUCEMIA MIELOIDE AGUDA

Hematology, Transfusion and Cell Therapy, 2023
Objetivo: Atualmente, a ampla aplicação da imunofenotipagem e caracterização genética tornou-se fundamental para refinamento diagnóstico, estratificação de risco, predição de prognóstico e promoção de terapia-alvo em pacientes com Leucemia Mieloide Aguda
FMCP Pessoa, IV Barreto, RB Gadelha, BMD Nogueira, AKC Machado, RM Ribeiro, DS Oliveira, MEA Moraes, CA Moreira-Nunes, MOM Filho   +9 more
doaj   +1 more source

ASSOCIAÇÃO ENTRE PARÂMETROS IMUNOFENOTÍPICOS E ESTRATIFICAÇÃO DE RISCO DE PACIENTES PORTADORES DE LEUCEMIA MIELOIDE AGUDA

Hematology, Transfusion and Cell Therapy, 2023
Objetivo: Atualmente, a ampla aplicação da imunofenotipagem e caracterização genética tornou-se fundamental para refinamento diagnóstico, estratificação de risco, predição de prognóstico e promoção de terapia-alvo em pacientes com Leucemia Mieloide Aguda
FMCP Pessoa, IV Barreto, RB Gadelha, CB Machado, BMD Nogueira, AKC Machado, MEA Morais, MOM Filho, DS Oliveira, CA Moreir-Nunes   +9 more
doaj   +1 more source

Detection of a novel CBFB/MYH11 variant fusion transcript (K-type) showing partial insertion of exon 6 of CBFB gene using two commercially available multiplex RT-PCR kits

, 2009
We report on a 20-year-old man with acute myeloid leukemia (AML) showing a distinct novel CBFB/MYH11 variant fusion transcript. Initial results of bone marrow, chromosome, and flow cytometric analyses were not in accordance with the diagnosis of acute ...
이승태, 박태성, 이경아, 송재우, 이종한, 최종락   +5 more
core   +2 more sources

Detection and quantification of CBFB/MYH11 fusion transcripts in patients with inv(16)-positive acute myeloblastic leukemia by real-time RT-PCR

We used a newly established real-time RT-PCR assay for the quantification of the leukemia-specific CBFB/MYH11 transcripts in inv(16)-positive acute myeloblastic leukemia.
Bunjes D, Wattjes MP, Ganser A, Hoellge W, Krauter J, Nagel S, Heil G, Heidenreich O   +7 more
core   +5 more sources

Case Report: A Novel Activating FLT3 Mutation in Acute Myeloid Leukemia

Frontiers in Oncology, 2021
FMS-like tyrosine kinase 3 (FLT3) is among the most common driver genes recurrently mutated in acute myeloid leukemia (AML), accounting for approximately 30% of cases.
Samantha Bruno, Lorenza Bandini, Agnese Patuelli, Valentina Robustelli, Valentina Robustelli, Claudia Venturi, Manuela Mancini, Dorian Forte, Sara De Santis, Cecilia Monaldi, Alessandra Grassi, Gabriella Chiurumbolo, Stefania Paolini, Gianluca Cristiano, Cristina Papayannidis, Chiara Sartor, Jacopo Nanni, Emanuela Ottaviani, Antonio Curti, Michele Cavo, Michele Cavo, Simona Soverini   +21 more
doaj   +1 more source

Identification of a novel CBFB-MYH11 transcript: implications for RT-PCR diagnosis.

, 2001
Item does not contain fulltextINTRODUCTION:: The chromosome rearrangements inv(16)(p13q22) or t(16;16)(p13;q22) are present in approximately 10% of all cases with de novo acute myeloid leukemia and define a subgroup with a favorable prognosis.
Erna B Luiten, Gabert, J., Lafage-Pochitaloff, M, Luiten, E.B., Wit, L. de, Löwenberg, Bob; id_orcid, Poel, S.C. van der, Jansen, J.H., Dastugue, N, Dastugue, N., de Wit, L, Lowenberg, B., Joop H Jansen, Lafage-Pochitaloff, M., Marina Lafage-Pochitaloff, Bert A Van der Reijden, Linda de Wit, Nicole Dastugue, Sonja van der Poel, Jean Gabert, Luiten, EB, Gabert, J, van der Poel, S, Reijden, B.A. van der, Bob Löwenberg, Reijden, BA, Jansen, JH (Joop)   +26 more
core   +1 more source

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus

, 2011
Recent studies suggest that the chromosome 16 inversion, associated with acute myeloid leukemia M4Eo, takes place in hematopoietic stem cells. If this is the case, it is of interest to know the effects of the resulting fusion gene, CBFB-MYH11, on other ...
Liu, P. Paul, Castilla, Lucio H., Cannons, Jennifer, Zhao, Ling, Kirby, Martha, Anderson, Stacie, Schwartzberg, Pamela L., Xu, Liping, Bosselut, Remy   +8 more
core   +1 more source

GASTROINTESTINAL MYELOID SARCOMA A CASE PRESENTATION AND CRITICAL REVIEW OF THE LITERATURE

Mediterranean Journal of Hematology and Infectious Diseases, 2021
Myeloid sarcomas can be detected in up to 30% of acute myeloid leukemia cases or occur de-novo without bone marrow involvement. The most frequent localization of myeloid sarcomas in the abdominal cavity is the small intestine, and gastric presentations ...
Pouyan Kheirkhah, Ana M. Avila-Rodriguez, Bartlomiej Radzik, Carlos Murga-Zamalloa   +3 more
doaj   +1 more source

Unlocking the Genetic Vault of Acute Myeloid Leukaemia: A Series of Five Cases [PDF]

National Journal of Laboratory Medicine
Acute Myeloid Leukaemia (AML) is a rare disease in children, accounting for approximately 15-20% of paediatric leukaemic cases.Acute Lymphoblastic Leukaemia (ALL) is the most common cause of paediatric leukaemia with a better prognosis.
M Srividhya, M Dougul Regis, K Chandramouleeswari, Umadevi Srinivasan, B Meenakumari   +4 more
doaj   +1 more source

Old data, new tricks: Comprehensive computational analysis of 10 years of multi‐center EuroFlow acute myeloid leukemia diagnostic immunophenotypic data

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Acute myeloid leukemia (AML) is characterized by high genotypic and immunophenotypic heterogeneity. We collected an extensive dataset containing 5366 flow cytometry files from 885 AML patients, stained with the EuroFlow acute leukemia orientation tube (ALOT) and AML/MDS panel, acquired in a standardized way at eight centers over a period of 10 
Sarah Bonte, Rosan Olsman, Sofie Van Gassen, Sergio Matarraz, Neus Villamor, Stefan Nierkens, Paula Fernandez, Elaine Sobral da Costa, Carmen‐Mariana Aanei, Alberto Orfao, Jacques J. M. van Dongen, Yvan Saeys, Mattias Hofmans, Vincent H. J. van der Velden   +13 more
wiley   +1 more source