Results 71 to 80 of about 74,876 (293)
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
, 2018 Desert sands in Iran, which usually contain small amounts of silt and sulfate, do not have significant strength, and thus, are not suitable for foundations or road construction.
A. Ghorbani, H. Hasanzadehshooiili
semanticscholar +1 more source
Multi-Agent-Based CBR Recommender System for Intelligent Energy Management in Buildings
IEEE Systems Journal, 2019 This paper proposes a novel case-based reasoning (CBR) recommender system for intelligent energy management in buildings. The proposed approach recommends the amount of energy reduction that should be applied in a building in each moment, by learning ...
T. Pinto +5 more
semanticscholar +1 more source
Behaviorally Adaptive and Inclusive Advanced Driver‐Assistance Systems
Advanced Intelligent Systems, EarlyView.Advanced driver‐assistance systems (ADASs) are mapped as evolving human‐centered, adaptive technologies linking sensing, driver monitoring, AR/HUD interfaces, patents, regulation, and inclusive design. The review identifies gaps in real‐world evidence, diverse‐driver validation, gaze metrics, and governance, outlining a roadmap for safer, behaviorally ...
Jana Skirnewskaja +2 more
wiley +1 more source
Inhaled liposomal ciprofloxacin protects against lethal tularemia in the common marmoset
Antimicrobial Agents and ChemotherapyFrancisella tularensis is a gram-negative, intracellular bacterium that causes the disease tularemia. Tularemia is prevalent in North America, Europe, and Asia and is typically treated with injected and orally administered antibiotics, including ...
Rachel E. Ireland +8 more
doaj +1 more source
AI &Innovation, EarlyView.ABSTRACT This study examines how organizations advance in their use of Generative AI (GenAI) tools after initial adoption with particular attention to the dynamics of trust, cultural resistance, and feedback mechanisms. Grounded in organizational learning theory and institutional theory, we propose a framework that captures the factors influencing how ...
Surajit Bag +3 more
wiley +1 more source
The Baltic Journal of Road and Bridge Engineering, 2020 In road construction projects, due to the high volume of soil materials, the costs of supplying and transporting high-quality materials are very high, they may also include the crossing between different geotechnical lands with different types of soils ...
Mahdi Zirak Baroughi +2 more
doaj +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Immune‐mediated thrombotic thrombocytopenic purpura (iTTP) is a life‐threatening thrombotic microangiopathy characterized by acute neurological manifestations and long‐term sequelae related to microvascular brain injury. Cerebral small vessel disease (cSVD), detectable on MRI through lacunes, microbleeds, white matter hyperintensities, and ...
Addolorata Truma +13 more
wiley +1 more source
An assessment of how penetration curve adjustment affects the California bearing ratio (CBR)
Studia Geotechnica et Mechanica, 2021 With the rapidly developing road transport, there is a demand for new roads to be constructed and for the existing ones to be repaired or extended. The base of any road is its foundation, usually made of crushed or uncrushed aggregate.
Bednarek Łukasz
doaj +1 more source
Strukturelle und chemische Dynamik von Cu/NiO/Cu(100)‐Oberflächen während der CO2‐Hydrierung
Angewandte Chemie, EarlyView.Dynamische Segregation als Designprinzip für Cu–Ni‐Katalysatoren. Operando‐LEEM/XPEEM verfolgt Reduktions‐, Umstrukturierungs‐ und Oberflächensegregationsprozesse in Cu‐verkapselten NiO‐Inseln auf Cu(100) während der CO2‐Hydrierung. ZUSAMMENFASSUNG Das Verständnis der dynamischen Umstrukturierung bimetallischer Katalysatoren unter Reaktionsbedingungen ...
Mauricio J. Prieto +9 more
wiley +1 more source