Results 1 to 10 of about 94,878 (326)

Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists [PDF]

Nature, 2016
CC chemokine receptor 2 (CCR2) is one of 19 members of the chemokine receptor subfamily of human class A G-protein-coupled receptors. CCR2 is expressed on monocytes, immature dendritic cells, and T-cell subpopulations, and mediates their migration ...
Yi Zheng, L. Qin, Natalia V. Ortiz Zacarías, H. de Vries, G. Han, Martin Gustavsson, M. Dabros, Chunxia Zhao, R. Cherney, P. Carter, Dean P Stamos, R. Abagyan, V. Cherezov, R. Stevens, A. IJzerman, L. Heitman, A. Tebben, I. Kufareva, T. Handel   +18 more
semanticscholar   +6 more sources

Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica

BMC Neurology, 2010
Background The role of different chemokine receptors in the pathogenesis of multiple sclerosis (MS) has been extensively investigated; however, little is known about the difference in the role of chemokine receptors between the pathogenesis of ...
Nomura Fumio, Masuda Saeko, Hayakawa Sei, Mori Masahiro, Uzawa Akiyuki, Kuwabara Satoshi   +5 more
doaj   +1 more source

Crucial biological functions of CCL7 in cancer [PDF]

PeerJ, 2018
Chemokine (C-C motif) ligand 7 (CCL7), a CC chemokine, is a chemotactic factor and attractant for various kinds of leukocytes, including monocytes and neutrophils.
Yangyang Liu, Yadi Cai, Li Liu, Yudong Wu, Xiangyang Xiong   +4 more
doaj   +2 more sources

An Update on the Chemokine System in the Development of NAFLD

Medicina, 2022
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Sustained hepatic inflammation is a key driver of the transition from simple fatty liver to nonalcoholic steatohepatitis (NASH), the more aggressive form of ...
Naoto Nagata, Guanliang Chen, Liang Xu, Hitoshi Ando   +3 more
doaj   +1 more source

P2X4 receptors and neuropathic pain

Frontiers in Cellular Neuroscience, 2013
Neuropathic pain, a debilitating pain condition, is a common consequence of damage to the nervous system. Neuropathic pain is often resistant to currently available analgesics.
Makoto eTsuda, Takahiro eMasuda, Hidetoshi eTozaki-Saitoh, Kazuhide eInoue   +3 more
doaj   +1 more source

CC Chemokines in Idiopathic Pulmonary Fibrosis: Pathogenic Role and Therapeutic Potential

Biomolecules, 2023
Idiopathic pulmonary fibrosis (IPF), characterized by progressive worsening of dyspnea and irreversible decline in lung function, is a chronic and progressive respiratory disease with a poor prognosis.
Shanshan Liu, Chang Liu, Qianrong Wang, Suosi Liu, Jiali Min   +4 more
doaj   +1 more source

Re: Chemokines in Cancer

Journal of Urological Surgery, 2016
Chemokines are chemotactic cytokines that regulate the trafficking and positioning of cells by activating the seven-transmembrane spanning G protein-coupled chemokine receptors (GPCR) or non G protein-coupled seven-transmembrane spanning receptors called
Fehmi Narter
doaj   +1 more source

Repression of enhancer RNA PHLDA1 promotes tumorigenesis and progression of Ewing sarcoma via decreasing infiltrating T‐lymphocytes: A bioinformatic analysis

Frontiers in Genetics, 2022
Background: The molecular mechanisms of EWS-FLI-mediating target genes and downstream pathways may provide a new way in the targeted therapy of Ewing sarcoma.
Runzhi Huang, Runzhi Huang, Runzhi Huang, Dan Huang, Siqiao Wang, Shuyuan Xian, Yifan Liu, Minghao Jin, Xinkun Zhang, Shaofeng Chen, Xi Yue, Wei Zhang, Jianyu Lu, Huizhen Liu, Zongqiang Huang, Zongqiang Huang, Hao Zhang, Huabin Yin   +17 more
doaj   +1 more source

Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true

Memorias do Instituto Oswaldo Cruz, 2009
One hundred years ago, Carlos Chagas discovered a new disease, the American trypanosomiasis. Chagas and co-workers later characterised the disease's common manifestation, chronic cardiomyopathy, and suggested that parasitic persistence coupled with ...
Joseli Lannes-Vieira, Jaline Coutinho Silverio, Isabela Resende Pereira, Nathália Ferreira Vinagre, Cristiano Marcelo Espinola Carvalho, Cláudia Neto Paiva, Andréa Alice da Silva   +6 more
doaj   +1 more source

Chemokines and immunity

Einstein (São Paulo)
Chemokines are a large family of small cytokines and generally have low molecular weight ranging from 7 to 15kDa. Chemokines and their receptors are able to control the migration and residence of all immune cells.
Diana Carolina Torres Palomino, Luciana Cavalheiro Marti   +1 more
doaj   +1 more source