CC Chemokine Receptors in Lung Adenocarcinoma: The Inflammation-Related Prognostic Biomarkers and Immunotherapeutic Targets [PDF]
Journal of Inflammation Research, 2021 Fangteng Liu,1,2 Hengyu Wu1 1Department of Breast Surgery, The Third Hospital of Nanchang, Nanchang, Jiangxi, 330009, People’s Republic of China; 2Faculty of Medicine, University of Munich, Munich, 80336, GermanyCorrespondence: Hengyu Wu Tel +86 ...
Liu F, Wu H
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CC chemokine receptors are prognostic indicators of gastric cancer and are associated with immune infiltration [PDF]
BMC Medical GenomicsBackground CC chemokine receptors are responsible for regulating the tumor microenvironment (TME) and participating in carcinogenesis and tumor advancement.
Xinghe Liao +4 more
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CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis [PDF]
Memorias do Instituto Oswaldo Cruz, 2005 The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control.
APMP Marino +6 more
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Chemokines and their receptors in oral squamous cell carcinoma: mechanisms, clinical significance, and therapeutic implications [PDF]
Frontiers in ImmunologyChemokines, a category of cytokines exhibiting chemotactic properties, have been thoroughly investigated as targets in cancer treatment in recent decades.
Dandan Li +6 more
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Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor-A Literature Review. [PDF]
Int J Mol Sci, 2020 Korbecki J +6 more
europepmc +3 more sources
Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]
Frontiers in Immunology, 2018 The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Erich Piovan +6 more
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Genetic Variations in CC Chemokine Receptors and Hypertension [PDF]
American Journal of Hypertension, 2006 CC-chemokine receptor 5 (CCR5) is a co-receptor for human immunodeficiency virus type 1 (HIV-1) infection. Homozygosity for a 32-base pair (bp) deletion (Delta32) in the CCR5 gene confers resistance to HIV-1. Previous studies found an increased prevalence of hypertension among CCR5-Delta32 homozygotes and among carriers of a polymorphism (CCR2-64I ...
M ZHANG +5 more
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Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]
PLoS Computational Biology, 2018 Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer +2 more
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Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
Cell Discovery, 2022 Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao +21 more
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Genes and Diseases, 2022 Obesity-induced inflammation, characterized by augmented infiltration and altered balance of macrophages, is a critical component of systemic insulin resistance. Chemokine-chemokine receptor system plays a vital role in the macrophages accumulation.
Min Xu +8 more
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