Results 91 to 100 of about 94,878 (326)

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors.

Journal of Immunology, 1999
The CC chemokine known as 6Ckine (SLC, Exodus-2, or TCA4) has been identified as a ligand for CCR7. Mouse 6Ckine has also been shown to signal through mouse CXCR3 and share some of the activities of IFN-gamma inducible protein 10 and monokine induced by ...
C. Jenh, M. A. Cox, Heather Kaminski, Meng Zhang, H. Byrnes, Jay S. Fine, D. Lundell, Chuan-Chu Chou, Satwant K. Narula, P. Zavodny   +9 more
semanticscholar   +1 more source

Novel biomarkers of inflammation-associated immunity in cervical cancer

Frontiers in Oncology
BackgroundCervical cancer (CC) is a highly malignant gynecological cancer with a direct causal link to inflammation, primarily resulting from persistent high-risk human papillomavirus (HPV) infection.
Weihong Zhao, Qi Li, Qi Li, Songquan Wen, Songquan Wen, Yaqin Li, Ying Bai, Ying Bai, Zhiyu Tian, Zhiyu Tian   +9 more
doaj   +1 more source

Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis

Arthritis Research & Therapy, 2018
Background B cells exert their pathogenic action in rheumatoid arthritis (RA) locally in the synovium. This study was undertaken to elucidate the chemokines responsible for the recruitment of B cells in the inflamed synovium, taking into account that the
Estefanía Armas-González, María Jesús Domínguez-Luis, Ana Díaz-Martín, Mayte Arce-Franco, Javier Castro-Hernández, Gabriela Danelon, Vanesa Hernández-Hernández, Sagrario Bustabad-Reyes, Alberto Cantabrana, Mariagrazia Uguccioni, Federico Díaz-González   +10 more
doaj   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

Advanced Functional Materials, EarlyView.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin   +7 more
wiley   +1 more source

As quimiocinas e os seus receptores: características e funções fisiológicas.

Acta Médica Portuguesa, 2011
Chemokines are members of a large family of small soluble proteins, which were discovered by their adhesion control, chemotaxis and leukocyte activation abilities.
Rita Guerreiro, Quirina Santos-Costa, J M Azevedo-Pereira   +2 more
doaj   +1 more source

Targeting Spare CC Chemokine Receptor 5 (CCR5) as a Principle to Inhibit HIV-1 Entry*

Journal of Biological Chemistry, 2014
Background: CCR5 is a chemokine receptor and a coreceptor for HIV entry. Results: A pool of spare CCR5 binds the potent anti-HIV chemokine analog PSC-RANTES but not native chemokines.
Jun Jin, P. Colin, Isabelle Staropoli, Evelyne Lima-Fernandes, Cécile Ferret, A. Demir, S. Rogée, O. Hartley, C. Randriamampita, M. Scott, S. Marullo, N. Sauvonnet, F. Arenzana‐Seisdedos, B. Lagane, A. Brelot   +14 more
semanticscholar   +1 more source

A Study of CD4, CCR3, CCR4, CCR5, CXCR3 Expression in Peripheral Blood Lymphocytes of Patients with Gastric Cancer

مجله دانشکده پزشکی اصفهان, 2012
Background: Based on the different expression of chemokine receptors in immune cells, we hypothesized that there would be an alteration in the relative expression of these receptors by T helper cells (Th1 and Th2) during the progression of a malignancy ...
Alireza Andalib, Hassan Dolabi, Abbas Rezaei, Mohamad Reza Maracy, Seyed Javad Hasheminia   +4 more
doaj  

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS Pathogens, 2008
The vaccinia virus (VACV) A41L gene encodes a secreted 30 kDa glycoprotein that is nonessential for virus replication but affects the host response to infection.
Mohammad W Bahar, Julia C Kenyon, Mike M Putz, Nicola G A Abrescia, James E Pease, Emma L Wise, David I Stuart, Geoffrey L Smith, Jonathan M Grimes   +8 more
doaj   +1 more source