Results 101 to 110 of about 94,878 (326)

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Epigenetic regulation of CC-chemokine ligand 2 in nonresolving inflammation

Biomolecular Concepts, 2014
Inflammation mediated by the crosstalk between leukocytes and resident tissue cells is crucial for the maintenance of homeostasis. Because chemokine ligands and receptors, which recruit a variety of leukocytes, are widely distributed among tissues, it is
Kiguchi Norikazu, Saika Fumihiro, Kobayashi Yuka, Kishioka Shiroh   +3 more
doaj   +1 more source

Impact of Erythrocyte Duffy Antigen Genetic Polymorphism on the Distribution of GroB-T, a Novel Human CXC Chemokine

Journal of Pharmacy & Pharmaceutical Sciences, 2007
Purpose. GroB-T, a human CXC chemokine, has been studied for its potential to mobilize stem cells. Chemokines bind specifically to receptors on target immune cells but also to a homologous erythrocyte blood group antigen, the Duffy Antigen/Receptor for ...
Timothy W Hepburn, LeeAnn P Tobia, Wei Shi, Timothy A McIntyre, Charles B Davis   +4 more
doaj   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

High CC chemokine receptor 7 expression improves postoperative prognosis of lung adenocarcinoma patients

British Journal of Cancer, 2013
Background:Chemokines and chemokine receptors not only have significant roles in cancer metastasis and tumorigenesis but also act as antitumour agents.
M. Itakura, Y. Terashima, M. Shingyoji, S. Yokoi, M. Ohira, H. Kageyama, Y. Matui, Yasuko Yoshida, H. Ashinuma, Y. Moriya, H. Tamura, K. Harigaya, K. Matushima, T. Iizasa, Akira Nakagawara, Hiroshi Kimura   +15 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

CC Chemokine Ligand 20 and Its Cognate Receptor CCR6 in Mucosal T Cell Immunology and Inflammatory Bowel Disease: Odd Couple or Axis of Evil?

Frontiers in Immunology, 2013
Chemokines and their cognate receptors have been identified as major factors initiating and governing cell movement and interaction. These ligands and their receptors are expressed on a wide variety of cells and act during steady-state migration as well ...
Adrian Y. S. Lee, R. Eri, A. Lyons, M. Grimm, H. Korner   +4 more
semanticscholar   +1 more source

Chemotactic Cues for NOTCH1-Dependent Leukemia

Frontiers in Immunology, 2018
The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Erich Piovan, Erich Piovan, Valeria Tosello, Alberto Amadori, Alberto Amadori, Paola Zanovello, Paola Zanovello   +6 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Exploring Chemokine Homodimer Stability: Structural Insights into CXC and CC Interfaces

Biophysica
Chemokine ligands play a pivotal role in immune response by mediating cell migration and coordinating cellular processes through interactions with chemokine receptors. Understanding their sequence and structural integrity is crucial for elucidating their
David Budean, Yasser Almeida-Hernández, Jitendra Pandey, Joel Mieres Pérez, Elsa Sánchez García, Ellinor Haglund   +5 more
doaj   +1 more source