Results 171 to 180 of about 94,878 (326)
Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis
, 2000 Bernhard Homey, Marie‐Caroline Dieu‐Nosjean, Andrea Wiesenborn, Catherine Massacrier, Jean‐Jacques Pin, Elizabeth R. Oldham, Daniel Catron, Matthew E. Buchanan, Anja Müller, René de Waal Malefyt, Glenn Deng, Rocio Orozco, Thomas Ruzicka, Percy Lehmann, Serge Lebecque, Christophe Caux, Albert Zlotnik +16 moreopenalex +1 more sourceGlucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation
Advanced Science, EarlyView.Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu +9 morewiley +1 more sourceCathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis
Advanced Science, EarlyView.CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang +10 morewiley +1 more sourceIdentification and Characterization of a Potent, Selective, and Orally Active Antagonist of the CC Chemokine Receptor-1
, 2000 Meina Liang, Cornell Mallari, Mary P. Rosser, Howard P. Ng, Karen May, Sean Monahan, John G. Bauman, Imadul Islam, Ameen Ghannam, Brad O. Buckman, Ken Shaw, Guo-Ping Wei, Wei Xu, Zuchun Zhao, Elena Ho, Jun Shen, Huynh Oanh, Babu Subramanyam, Ron Vergona, Dennis D. Taub, Laura Dunning, Susan Harvey, R. Michael Snider, Joseph Hesselgesser, Michael M. Morrissey, H. Daniel Perez, Richard Horuk +26 moreopenalex +1 more sourceGenetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics [PDF]
, 2001 K. Fukunaga, Koichiro Asano, X.‐Q. Mao, P‐S. Gao, Mark H. Roberts, T. Oguma, Tetsuya Shiomi, M. Kanazawa, C.N. Adra, Taro Shirakawa, J. M. Hopkin, Kazuhiro Yamaguchi +11 moreopenalex +1 more sourceTargeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition
Advanced Science, EarlyView.The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang +20 morewiley +1 more source
