Results 181 to 190 of about 94,878 (326)

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes [PDF]

, 2001
Marc‐André Wurbel, Marie Malissen, Delphine Guy‐Grand, Eric Meffre, Michel C. Nussenzweig, Mireille Richelme, Alice Carrier, Bernard Malissen   +7 more
openalex   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology

Advanced Science, EarlyView.
This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou, Yuwei Wang, Yu Liu, Feipeng Zhu, Ge Gao, Chengjie Li, Pu Ai, Jingying Xu, Junxin Wang, Long Guo, Yuting Guan, Virginia Man‐Yee Lee, Jianjun Chen, Jialin Zheng, Qihui Wu   +14 more
wiley   +1 more source

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

Advanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji, Yongli Ye, Jiadi Sun, Lina Sheng, Jinyou Li, Jin Yang, Bing Wu, Yuting Wang, Xingxing Gao, Liang Luo, Jianfeng Ping, Yinzhi Zhang, Xiulan Sun   +12 more
wiley   +1 more source

Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization

Advanced Science, EarlyView.
In tumor cells, ENH prompts the interaction between YAP and KPNA2. This interaction enables YAP to translocate into the nucleus, where it enhances the transcription of CCL5. Consequently, this up‐regulation of CCL5 drives the infiltration of tumor‐associated macrophages (TAMs) and their polarization toward the M2 phenotype, ultimately facilitating ...
Yueli Shi, Zhiyong Xu, Huan Wang, Bufu Tang, Nueraili Maihemuti, Xinyuan Jiang, Xiuying Chen, Mingshu Xiao, Sujing Jiang, Yun Xu, Peng Xiao, Jiangnan Zhao, Kaiyue Zhang, Mengshu Li, Kai Wang   +14 more
wiley   +1 more source

1108 Expression of CC-chemokine receptors in the human bronchial epithelial cell line BEAS-2B

, 2000
Syed Shahabuddin
openalex   +1 more source

Expression of Human Immunodeficiency Virus Coreceptors CXC Chemokine Receptor 4 and CC Chemokine Receptor 5 on Monocytes Is Down‐regulated during Human Endotoxemia [PDF]

, 2002
Nicole P. Juffermans, Sebastiaan Weijer, Annelies Verbon, Peter Speelman, Tom van der Poll   +4 more
openalex   +1 more source

Reprogramming of Fatty Acid Metabolism via PPARα‐Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis

Advanced Science, EarlyView.
This study identifies fatty acid desaturase 2 (FADS2) as a key regulator linking polyunsaturated fatty acid (PUFA) metabolism to psoriatic inflammation. FADS2 deficiency impairs docosahexaenoic acid (DHA) biosynthesis, enhances NF‐κB signaling, and promotes neutrophil‐driven skin inflammation. PPARα transcriptionally activates FADS2, and its activation
Jiangluyi Cai, Xue Zhou, Yu Zhuang, Lian Cui, Rui Ma, Youdong Chen, Nan Yang, Qianyu Chen, Yuanyuan Wang, Peiyao Zhu, Lingling Yao, Qian Yu, Xiaomin She, Xuyang Zhou, Yuemeng Huang, Zengyang Yu, Xilin Zhang, Jiajing Lu, Yuling Shi, Chunyuan Guo   +19 more
wiley   +1 more source