Results 11 to 20 of about 94,878 (326)

CC Chemokine Receptors in Lung Adenocarcinoma: The Inflammation-Related Prognostic Biomarkers and Immunotherapeutic Targets. [PDF]

J Inflamm Res, 2021
Background Lung adenocarcinoma (LUAD) is the most common type of lung cancer with a high incidence and increased mortality. CC chemokine receptors were participating in the modulation of the tumor microenvironment and involved in carcinogenesis and tumor
Liu F, Wu H.
europepmc   +4 more sources

Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor-A Literature Review. [PDF]

Int J Mol Sci, 2020
Hypoxia, i.e., oxygen deficiency condition, is one of the most important factors promoting the growth of tumors. Since its effect on the chemokine system is crucial in understanding the changes in the recruitment of cells to a tumor niche, in this review
Korbecki J, Kojder K, Barczak K, Simińska D, Gutowska I, Chlubek D, Baranowska-Bosiacka I.   +6 more
europepmc   +6 more sources

Differential Activation of CC Chemokine Receptors by AOP-RANTES* [PDF]

Journal of Biological Chemistry, 2000
RANTES (regulated on activation normal T cell expressed) has been found at elevated levels in biological fluids from patients with a wide range of allergic and autoimmune diseases and is able to attract several subtypes of leukocytes including ...
J. Elsner, M. Mack, H. Brühl, Y. Dulkys, D. Kimmig, G. Simmons, P. Clapham, D. Schlöndorff, A. Kapp, T. Wells, A. Proudfoot   +10 more
semanticscholar   +6 more sources

Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2. [PDF]

J Med Chem, 2018
The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding site.
Ortiz Zacarías NV, van Veldhoven JPD, Portner L, van Spronsen E, Ullo S, Veenhuizen M, van der Velden WJC, Zweemer AJM, Kreekel RM, Oenema K, Lenselink EB, Heitman LH, IJzerman AP.   +12 more
europepmc   +2 more sources

Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation. [PDF]

BMC Cancer, 2014
BackgroundChemokines have been implicated in tumor progression and metastasis. In melanoma, chemokine receptors have been implicated in organ selective metastasis by regulating processes such as chemoattraction, adhesion and survival.MethodsIn this study
Pinto S, Martínez-Romero A, O'Connor JE, Gil-Benso R, San-Miguel T, Terrádez L, Monteagudo C, Callaghan RC.   +7 more
europepmc   +2 more sources

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3

Cell Discovery, 2022
Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao, Yangxia Tan, Q. Shen, L. Hou, Bingpeng Yao, Jiao Qin, P. Xu, C. Mao, Li-Nan Chen, Huibing Zhang, D. Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhihua Chen, Yi Jiang, H. Xu, S. Ying, Honglei Ma, Yan Zhang, Huahao Shen   +21 more
semanticscholar   +2 more sources

CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis.

Memorias do Instituto Oswaldo Cruz, 2005
The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control.
A. P. Marino, Andrea Alice da Silva, Andrea Alice da Silva, Paula V.A. dos Santos, Luzia M. O. Pinto, R. T. Gazinelli, R. T. Gazinelli, Mauro M. Teixeira, J. Lannes-Vieira   +8 more
semanticscholar   +3 more sources

CC chemokine receptors are prognostic indicators of gastric cancer and are associated with immune infiltration. [PDF]

BMC Med Genomics
Background CC chemokine receptors are responsible for regulating the tumor microenvironment (TME) and participating in carcinogenesis and tumor advancement.
Liao X, Yang Y, Wang L, Kong Z, Li W.
europepmc   +2 more sources

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist [PDF]

Science Advances, 2020
The structure of CCR5 in complex with [6P4]CCL5 and the Gi protein reveals its activation mechanism. The human CC chemokine receptor 5 (CCR5) is a G protein–coupled receptor (GPCR) that plays a major role in inflammation and is involved in cancer, HIV ...
Polina Isaikina, Ching-Ju Tsai, N. Dietz, F. Pamula, A. Grahl, K. Goldie, Ramon Guixà-González, Camila Branco, Marianne Paolini‐Bertrand, Nicolas Calo, F. Cerini, G. Schertler, Oliver Hartley, Henning Stahlberg, Tim Maier, X. Deupí, Stephan Grzesiek   +16 more
semanticscholar   +10 more sources

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities

Scientific Reports, 2017
Chemokines function via G-protein coupled receptors in a robust network to recruit immune cells to sites of inflammation. Due to the complexity of this network, targeting single chemokines or receptors has not been successful in inflammatory disease. Dog
Kamayani Singh, G. Davies, Yara Alenazi, James R. O. Eaton, A. Kawamura, S. Bhattacharya   +5 more
semanticscholar   +2 more sources