Results 251 to 260 of about 94,878 (326)

PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages

Advanced Science, EarlyView.
Polyvinyl chloride (PVC) nanoplastics (NPs) are shown to aggravate allergic airway inflammation in asthma by triggering R‐loop accumulation and activating the cGAS‐STING pathway in macrophages. This study reveals a novel immunotoxic mechanism linking environmental plastic exposure to asthma pathogenesis and highlights potential molecular targets for ...
Qimei Bao, Yixing Huang, Mingcong Deng, Chunkai Zhang, Dan Zu, Hanyi He, Yangchan Hu, Yuke Zhong, Chen Liang, Haidong Liu, Wumin Dai, Yanhua He, Yaoshu Teng, Ji Jing, Yin Shi, Xiangdong Cheng, Zu Ye   +16 more
wiley   +1 more source

Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer. [PDF]

J Immunother Cancer
Ding J, Hu H, Zhu Y, Xu X, Yin B, Yang M, Zhou H, Huang T, Li M, Kou Y, Rahim Z, Huang B, Li A, Wang W, Han L.   +14 more
europepmc   +1 more source

Atypical chemokine receptors in cancer: friends or foes?

Journal of Leukocyte Biology, 2016
M. Massara, Ornella Bonavita, A. Mantovani, M. Locati, R. Bonecchi   +4 more
semanticscholar   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

Exploring the therapeutic potential of H1-antihistamines in endometriosis-A gene regulation-based perspective. [PDF]

Front Med (Lausanne)
Mantha KB, Gajendran MK.
europepmc   +1 more source

Cryogel‐Based Dendritic Cell Immunotherapy for Post‐Surgical Breast Cancer Treatment

Advanced Science, EarlyView.
A multifunctional GelMA cryogel enables dendritic cell immunotherapy that synergizes with doxorubicin and PD‐1 blockade, driving robust post‐surgical T‐cell immunity and suppressing TNBC recurrence. Abstract Triple‐negative breast cancer (TNBC) is an aggressive malignancy with high mortality and limited treatment options.
Lam‐Duc‐Huy Nguyen, Sheng‐Liang Cheng, Yu‐Ting Yen, Hsin‐Mei Lee, Te‐Haw Wu, Jane Wang, Shu‐Yi Lin, Yunching Chen   +7 more
wiley   +1 more source

Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis. [PDF]

Proc Natl Acad Sci U S A
Rad LM, Hughes KR, Wheeler SN, Decker JT, Orbach SM, Galvan A, Thornhill J, Griffin KV, Turkistani H, Urie RR, Irani DN, Shea LD, Morris AH.   +12 more
europepmc   +1 more source

Activation of select Src family tyrosine kinases by the CC chemokine receptor-3 (CCR3) in eosinophils

, 2003
R. Bloebaum, Tetsuya Adachi, Susan Stafford, Rafeul Alam   +3 more
openalex   +1 more source

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

Feed status and skin injury modulate immunopathology, global gene expression, and survival in channel catfish during virulent <i>Aeromonas hydrophila</i> infection. [PDF]

Front Immunol
Soku YK, Lange MD, Abernathy JW, Sankappa NM, Shoemaker CA, Hayden K, Andersen LK, Phillips I, Nashar T, Samuel T, Mohamed A.   +10 more
europepmc   +1 more source