Results 281 to 290 of about 94,878 (326)

mTOR inhibition impacts the flagellin-augmented inflammatory and antimicrobial response of human airway epithelial cells to Pseudomonas aeruginosa. [PDF]

PLoS One
van Linge CCA, Hulme KD, Peters-Sengers H, Kullberg RFJ, de Jong MD, Russell CA, de Vos AF, van der Poll T.   +7 more
europepmc   +1 more source

Dual‐Modular Hydrogel Microparticles with Precision‐Modulation of Inflammatory Microenvironment Dictate Full‐Thickness Cartilage Regeneration for Osteoarthritis Repair

Advanced Science, EarlyView.
Cartilage injury is a prominent pathological hallmark of osteoarthritis. In this study, we developed a two‐modular hydrogel microparticle system wherein HMP‐A effectively targets the damaged area, while HMP‐B forms an efficient connection with HMP‐A on the cartilage surface.
Xinye Chen, Yuanman Yu, Zirui He, Lina Pan, Jing Wang, Changsheng Liu   +5 more
wiley   +1 more source

The role of CXC chemokines and receptors in breast cancer. [PDF]

Clin Exp Med
Masrour M, Moeinafshar A, Poopak A, Razi S, Rezaei N.   +4 more
europepmc   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, EarlyView.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

The dual roles of chemokines in peripheral nerve injury and repair. [PDF]

Inflamm Regen
Wang F, Zhao C, Jing Z, Wang Q, Li M, Lu B, Huo A, Liang W, Hu W, Fu X.   +9 more
europepmc   +1 more source

Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals

Advanced Science, EarlyView.
Ionizing radiation disrupts gut virome and bacteriome. Gut commensal viruses protect against intestinal damage and promote stem cell regeneration by inhibiting hyperactivation of RIG‐I and Notch signaling in stem cells. Fecal virome transplantation (FVT) from healthy donors can serve as a potential therapeutic intervention by enriching phages targeting
Xiaotong Zhao, Yu Cai, Yujia Hou, Yanjin Wu, Tingting Wei, Lili Li, Zhaojun Duan, Xinran Lu, Jiahui Meng, Haitao Zhou, Qin Wang, Jinhan Wang, Chang Xu, Liqing Du, Saijun Fan, Feng Wang, Qiang Liu, Yang Liu   +17 more
wiley   +1 more source

Identification of potential drug targets and possible drugs for esophageal carcinoma from genetic insights: a comprehensive two-sample Mendelian randomization study. [PDF]

Discov Oncol
Wang J, Sun J, Liang C, Ou H, Liu J, Ye A, Wu Q, Liu Y.   +7 more
europepmc   +1 more source

Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells

Advanced Science, EarlyView.
Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho, Su Min Kim, Jiyeon Lee, Oh Chan Kwon, Wonjin Woo, Eunji Lee, Hyo Jin Park, Yeongun Lee, So Hee Dho, Tae‐Kyung Kim, Min‐Chan Park, Richard A. Flavell, Lark Kyun Kim   +12 more
wiley   +1 more source

Immunobiology roles of the human CD161 receptor in T cells. [PDF]

Front Immunol
Tong B, Wang M, Liu L, Yang X.
europepmc   +1 more source