Results 21 to 30 of about 94,878 (326)
Novel lymphocyte-specific CC chemokines and their receptors [PDF]
Journal of Leukocyte Biology, 1997 Abstract By using a cloning method termed the signal sequence trap as well as by searching for chemokine homologous sequences in the database of expressed sequence tags, cDNA fragments potentially encoding novel CC chemokines were initially identified. Using these sequences, we have cloned five novel human CC chemokines termed TARC, LARC,
Osamu Yoshie +2 more
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The CC Chemokine Eotaxin (CCL11) Is a Partial Agonist of CC Chemokine Receptor 2b [PDF]
Journal of Biological Chemistry, 2001 Despite sharing considerable homology with the members of the monocyte chemoattractant protein (MCP) family, the CC chemokine eotaxin (CCL11) has previously been reported to signal exclusively via the receptor CC chemokine receptor 3 (CCR3). Using the monocyte cell line THP-1, we investigated the relative abilities of eotaxin and MCPs 1-4 to induce ...
Roberta Martinelli +4 more
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CC Chemokine Receptor 5: The Interface of Host Immunity and Cancer [PDF]
Disease Markers, 2014 Solid tumors are embedded in a stromal microenvironment consisting of immune cells, such as macrophages and lymphocytes, as well as nonimmune cells, such as endothelial cells and fibroblasts.
C. D. de Oliveira +7 more
semanticscholar +4 more sources
Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours [PDF]
British Journal of Cancer, 2001 To understand the chemokine network in a tissue, both chemokine and chemokine receptor expression should be studied. Human epithelial ovarian tumours express a range of chemokines but little is known about the expression and localisation of chemokine receptors. With the aim of understanding chemokine action in this cancer, we investigated receptors for
Chris J. Scotton +4 more
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CXC and CC Chemokine Receptors on Coronary and Brain Endothelia [PDF]
Molecular Medicine, 1999 Chemokine receptors on leukocytes play a key role in inflammation and HIV-1 infection. Chemokine receptors on endothelia may serve an important role in HIV-1 tissue invasion and angiogenesis.The expression of chemokine receptors in human brain microvascular endothelial cells (BMVEC) and coronary artery endothelial cells (CAEC) in vitro and cryostat ...
Omri Berger +13 more
semanticscholar +4 more sources
Receptor-mediated Endocytosis of CC-chemokines [PDF]
Journal of Biological Chemistry, 1997 Chemokines are chemotactic proteins which play a central role in immune and inflammatory responses. Chemokine receptors are members of the seven transmembrane G-protein coupled family and have recently been shown to be involved in the entry of human immunodeficiency virus (HIV) into target cells.
Roberto Solari +7 more
openaire +3 more sources
Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]
PLoS Computational Biology, 2018 Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer +2 more
doaj +1 more source
STRL22 Is a Receptor for the CC Chemokine MIP-3α [PDF]
Biochemical and Biophysical Research Communications, 1997 STRL22 is a human seven transmembrane domain orphan receptor related to known chemokine receptors and expressed in peripheral blood lymphocytes, tumor infiltrating lymphocytes and lymphoid tissues. MIP-3alpha/LARC/Exodus is a CC chemokine that is chemotactic for lymphocytes and that is expressed in activated cells, including monocytes, T cells ...
Liao, Fang +5 more
openaire +3 more sources
Genes and Diseases, 2022 Obesity-induced inflammation, characterized by augmented infiltration and altered balance of macrophages, is a critical component of systemic insulin resistance. Chemokine-chemokine receptor system plays a vital role in the macrophages accumulation.
Min Xu +8 more
doaj +1 more source
Advanced Biomedical Research, 2023 Background: The studies reported that chemokines Chemokine (C-C motif) ligand 2 (CCL2) and Chemokine (C-C motif) ligand 5 (CCL5) have tumor-promoting roles in breast cancer (BC).
Mehrnoosh Esmailiyan +5 more
doaj +1 more source