Results 21 to 30 of about 88,115 (330)

The role of CXCR4 signaling in the migration of transplanted oligodendrocyte progenitors into the cerebral white matter

Neurobiology of Disease, 2011
Enhancing the ability of either endogenous or transplanted oligodendrocyte progenitors (OPs) to engage in myelination may constitute a novel therapeutic approach to demyelinating diseases of the brain.
Ghazal Banisadr, Terra J. Frederick, Caroline Freitag, Dongjun Ren, Hosung Jung, Stephen D. Miller, Richard J. Miller   +6 more
doaj   +1 more source

Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]

, 2010
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim, Sayyed, Sufyan Ali, Vielhauer, Volker   +2 more
core   +1 more source

HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism. [PDF]

PLoS ONE, 2014
Human and Simian Immunodeficiency virus (HIV-1, HIV-2, and SIV) encode an accessory protein, Nef, which is a pathogenesis and virulence factor. Nef is a multivalent adapter that dysregulates the trafficking of many immune cell receptors, including ...
Prabha Chandrasekaran, Victoria Moore, Monica Buckley, Joshua Spurrier, John H Kehrl, Sundararajan Venkatesan   +5 more
doaj   +1 more source

Structural Evidence for the Tetrameric Assembly of Chemokine CCL11 and the Glycosaminoglycan Arixtra™. [PDF]

, 2013
Understanding chemokine interactions with glycosaminoglycans (GAG) is critical as these interactions have been linked to a number of inflammatory medical conditions, such as arthritis and asthma.
Dykstra, Andrew B, Leary, Julie A, Sweeney, Matt D   +2 more
core   +2 more sources

The binding and specificity of chemokine binding proteins, through the lens of experiment and computation

Biomedical Journal, 2022
Chemokines are small proteins that are critical for immune function, being primarily responsible for the activation and chemotaxis of leukocytes. As such, many viruses, as well as parasitic arthropods, have evolved systems to counteract chemokine ...
Lauren E. Stark, Wenyan Guan, Michael E. Colvin, Patricia J. LiWang   +3 more
doaj   +1 more source

Dynamin function is important for chemokine receptor-induced cell migration. [PDF]

, 2015
The HIV viral entry co-receptors CCR5 and CXCR4 function physiologically as typical chemokine receptors. Activation leads to cytosolic signal transduction that results in a variety of cellular responses such as cytoskeletal rearrangement and chemotaxis ...
Arai, Bachelerie, Borroni, Casoli, Chua, De Camilli, Delgado-Martin, Drury, Ferguson, Gallo, Germena, Harper, Harper, Hill, Homey, Kawada, Kerr, Lagane, Lee, Loetscher, Magalhaes, Mariani, McCluskey, McGeachie, Meiser, Mueller, Mueller, Mueller, Rajagopal, Rajagopal, Sabroe, Scott, Shpetner, Tadagaki, Thelen, Tomizawa, Zhang, Zlotnik, Zlotnik   +38 more
core   +1 more source

The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]

, 2017
Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna, J LiWang, Patricia, Jian, Mike, S Schill, Megan   +3 more
core   +2 more sources

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities

Scientific Reports, 2017
Chemokines function via G-protein coupled receptors in a robust network to recruit immune cells to sites of inflammation. Due to the complexity of this network, targeting single chemokines or receptors has not been successful in inflammatory disease. Dog
Kamayani Singh, Graham Davies, Yara Alenazi, James R. O. Eaton, Akane Kawamura, Shoumo Bhattacharya   +5 more
doaj   +1 more source

Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes [PDF]

, 2007
CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated.
Borchers, Michael T., Lee, James J., Lund, Frances E., Misra, Ravi S., Partida-Sánchz, Santiago, Shi, Guixiu, Simon, Melvin I., Tighe, Michael   +7 more
core   +2 more sources

Genomic organization, annotation, and ligand-receptor inferences of chicken chemokines and chemokine receptor genes based on comparative genomics

BMC Genomics, 2005
Background Chemokines and their receptors play important roles in host defense, organogenesis, hematopoiesis, and neuronal communication. Forty-two chemokines and 19 cognate receptors have been found in the human genome.
Sze Sing-Hoi, Yilmaz Ahmet, Adelson David L, Wang Jixin, Jin Yuan, Zhu James J   +5 more
doaj   +1 more source