Results 301 to 310 of about 94,878 (326)
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Identification of a Mouse Eosinophil Receptor for the CC Chemokine Eotaxin
Biochemical and Biophysical Research Communications, 1996The CC chemokine eotaxin is a selective chemoattractant for eosinophils in vitro and induces eosinophil migration in vivo. Here we show that the mouse orphan receptor previously named macrophage inflammatory protein-1 alpha receptor-like 2 is a functional eotaxin receptor.
Anita I. Sen +6 more
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Polymorphisms in the human CC chemokine receptor-3 gene
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998CC chemokine receptor (CCR)-3 is a seven-transmembrane-spanning G-protein-coupled receptor (GPCR) that is involved in the recruitment of inflammatory cells in allergic responses and acts as a co-receptor for entry of HIV into cells. Selected polymorphisms in GPCRs have been shown to have dramatic effects on the manifestation and/or susceptibility to a ...
Marc E. Rothenberg +2 more
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CC chemokine receptor 5 and renal-transplant survival
The Lancet, 2001About 1% of white populations are homozygous carriers of an allele of the gene for the CC chemokine receptor 5 (CCR5) with a 32 bp deletion (CCR5Delta32), which leads to an inactive receptor. During acute and chronic transplant rejection, ligands for CCR5 are upregulated, and the graft is infiltrated by CCR5-positive mononuclear cells.
Bernhard K. Krämer +13 more
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Current Medical Science, 2004
In order to explore the possible role of CC chemokine ligand 20 (CCL20) and its receptor CC chemokine receptor 6 (CCR6) in the pathogenesis of psoriasis, the expression levels of mRNA of them in psoriatic lesions were investigated. The skin biopsies were collected from skin lesions in 35 cases of psoriasis vulgaris and 18 normal controls.
Jiawen Li, Yan Wu
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In order to explore the possible role of CC chemokine ligand 20 (CCL20) and its receptor CC chemokine receptor 6 (CCR6) in the pathogenesis of psoriasis, the expression levels of mRNA of them in psoriatic lesions were investigated. The skin biopsies were collected from skin lesions in 35 cases of psoriasis vulgaris and 18 normal controls.
Jiawen Li, Yan Wu
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The Molecular and Cellular Biology of CC Chemokines and Their Receptors
2005Publisher Summary This chapter discusses the molecular and cellular biology of CC chemokines and their receptors. Chemokines are low‐molecular‐weight proteins, typically basic, that show to activate and mediate the migration of leukocytes. The chemokine family consists of over 40 members, which are divided into two major and two minor families based ...
James M. Fox, James E. Pease
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Differential sensitivities of pyrogenic chemokine fevers to CC chemokine receptor 5 antibodies
Fundamental & Clinical Pharmacology, 2004AbstractMacrophage inflammatory protein (MIP)‐1β and RANTES (regulated on activation, normal T‐cells expressed and secreted) are members of the CC‐family of chemokines. Although these two peptides are structurally and functionally related to one another, each exhibits distinct features, which allows it to independently regulate specific aspects of the ...
Francisco J. Miñano, Eva Tavares
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CC chemokine receptor-coupled signalling pathways.
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 2004The isolation and characterization of multiple CC chemokine receptors (CCRs) in a wide range of tissues and cells signifies the functional diversity of CC chemokines. The realization that multiple chemokines activate individual receptors and that some chemokines are functional at several different CCRs, indicates that interplay between a complex ...
New, David C. BIOL, Wong, Yung Hou
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Role of the CC Chemokine receptor 9/TECK interaction in apoptosis
Apoptosis, 2002Chemokine receptors are members of the G protein coupled receptor (GPCR) supergene family whose expression is highly restricted to hematopoietic cells. Although the primary role of chemokine and chemokine receptor interaction is believed to be regulation of chemotaxis of leukocytes, subsequent information clearly suggests that multiple immune ...
K.-Y. Yu +5 more
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