Results 31 to 40 of about 94,878 (326)
Genetic Variations in CC Chemokine Receptors and Hypertension [PDF]
American Journal of Hypertension, 2006 CC-chemokine receptor 5 (CCR5) is a co-receptor for human immunodeficiency virus type 1 (HIV-1) infection. Homozygosity for a 32-base pair (bp) deletion (Delta32) in the CCR5 gene confers resistance to HIV-1. Previous studies found an increased prevalence of hypertension among CCR5-Delta32 homozygotes and among carriers of a polymorphism (CCR2-64I ...
Mingdong Zhang +6 more
openaire +3 more sources
Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5) [PDF]
Journal of Leukocyte Biology, 1999 Abstract The CC-chemokine receptor 5 (CCR5) mediates activation of T lymphocytes and macrophages by chemokines and is a major co-receptor for macrophage-tropic HIV-1 strains. Recently, it was shown that the natural CCR5 ligands RANTES, macrophage inflammatory protein-1á (MIP-1á), MIP-1β, and amino-terminal modifications of RANTES (Met ...
Martin Oppermann +2 more
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The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3 [PDF]
Proceedings of the National Academy of Sciences, 1998 We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine,
Hortensia Soto +7 more
openaire +3 more sources
Chemokine Receptors and Phagocyte Biology in Zebrafish
Frontiers in Immunology, 2020 Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs ...
Frida Sommer +2 more
doaj +1 more source
Biomedicines, 2023 Cervical cancer (CC) is a serious global health issue, and it is well-known that HPV infection is the main etiological factor that triggers carcinogenesis.
Leonardo Fernandez-Avila +5 more
doaj +1 more source
The role of CC chemokine receptor 5 in antiviral immunity [PDF]
Blood, 2002 The CC chemokine receptor CCR5 is an important coreceptor for human immunodeficiency virus (HIV), and there is a major thrust to develop anti-CCR5–based therapies for HIV-1. However, it is not known whether CCR5 is critical for a normal antiviral T-cell response.
Anneline Nansen +5 more
openalex +4 more sources
CC chemokine receptor 5 polymorphism in chronic periaortitis [PDF]
Rheumatology, 2011 Chronic periaortitis (CP) is a rare disease characterized by a fibro-inflammatory tissue surrounding the abdominal aorta, and includes non-aneurysmal [idiopathic retroperitoneal fibrosis (IRF)] and aneurysmal forms [inflammatory abdominal aortic aneurysm (IAAA)].
Boiardi, Luigi +12 more
openaire +5 more sources
A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation. [PDF]
PLoS ONE, 2012 Chemokines play a key role in leukocyte recruitment during inflammation and are implicated in the pathogenesis of a number of autoimmune diseases. As such, inhibiting chemokine signaling has been of keen interest for the development of therapeutic agents.
Michelle L Scalley-Kim +16 more
doaj +1 more source
CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy
International Journal of Molecular Sciences, 2022 Chemokines and their receptors participate in many biological processes, including the modulation of neuroimmune interactions. Approximately fifty chemokines are distinguished in humans, which are classified into four subfamilies based on the N-terminal ...
J. Bogacka +4 more
semanticscholar +1 more source
Characterization of the CC Chemokine Receptor 3 on Human Keratinocytes [PDF]
Journal of Investigative Dermatology, 2001 CC chemokine receptors are expressed on hematopoietic cells, and these may impart selective homing of monocyte, leukocyte, and lymphocyte subsets to sites of inflammation. CC chemokine receptor 3 is the major receptor on eosinophils and is also expressed on other inflammatory cells suggesting its important role for allergic diseases such as atopic ...
Yasmin Dulkys +6 more
openaire +3 more sources