Results 31 to 40 of about 88,115 (330)

Organ-specific features of natural killer cells. [PDF]

, 2011
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical.
La Cava, Antonio, Ljunggren, Hans-Gustaf, Shi, Fu-Dong, Van Kaer, Luc   +3 more
core   +1 more source

CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis [PDF]

, 2019
Allergic enteritis (AE) is a gastrointestinal form of food allergy. This study aimed to elucidate cellular and molecular mechanisms of AE using a murine model. To induce AE, BALB/c wild type (WT) mice received intraperitoneal sensitization with ovalbumin
Blanco Pérez, Frank, Burggraf, Manja, Gonzalez Menendez, Irene, Iwakura, Yoichiro, Kato, Yoichiro, Kirberg, Jörg, Krause, Maren, Laiño, Jonathan Emiliano, Martella, Manuela, Ohbayashi, Masaharu, Quintanilla Martinez, Leticia, Scheurer, Stephan, Shibata, Noriyuki, Toda, Masako, Vieths, Stefan   +14 more
core   +1 more source

Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment

Mediators of Inflammation, 2015
Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and
Sezin Günaltay, Ashok Kumar Kumawat, Nils Nyhlin, Johan Bohr, Curt Tysk, Olof Hultgren, Elisabeth Hultgren Hörnquist   +6 more
doaj   +1 more source

The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]

, 2018
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos, Amaral, Flávio Almeida, Borges, Vanessa, Castanheira, Fernanda Vargas E. Silva, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Donate, Paula Barbim, Graham, Gerard J., Kanashiro, Alexandre, Liew, Foo Y., Melo, Paulo Henrique, Pallas, Kenneth, Ramalho, Fernando Silva, Russo, Remo Castro, Sônego, Fabiane, Teixeira, Mauro Martins   +15 more
core   +1 more source

Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.

PLoS Biology, 2019
Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-
Kit Ming Lee, Gillian J Wilson, Marieke Pingen, Ayumi Fukuoka, Christopher A H Hansell, Robin Bartolini, Laura Medina-Ruiz, Gerard J Graham   +7 more
doaj   +1 more source

Receptor-mediated Endocytosis of CC-chemokines [PDF]

Journal of Biological Chemistry, 1997
Chemokines are chemotactic proteins which play a central role in immune and inflammatory responses. Chemokine receptors are members of the seven transmembrane G-protein coupled family and have recently been shown to be involved in the entry of human immunodeficiency virus (HIV) into target cells.
R, Solari, R E, Offord, S, Remy, J P, Aubry, T N, Wells, E, Whitehorn, T, Oung, A E, Proudfoot   +7 more
openaire   +2 more sources

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]

, 2016
BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus, Maung, Ricky, Medders, Kathryn E, Ojeda-Juárez, Daniel, Sanchez, Ana B, Sánchez-Pavón, Paloma   +5 more
core   +1 more source

Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility.

PLoS Pathogens, 2009
While most chemokine receptors fail to cross the chemokine class boundary with respect to the ligands that they bind, the human cytomegalovirus (HCMV)-encoded chemokine receptor US28 binds multiple CC-chemokines and the CX(3)C-chemokine Fractalkine. US28
Jennifer Vomaske, Ryan M Melnychuk, Patricia P Smith, Joshua Powell, Laurel Hall, Victor DeFilippis, Klaus Früh, Martine Smit, David D Schlaepfer, Jay A Nelson, Daniel N Streblow   +10 more
doaj   +1 more source

Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5) [PDF]

Journal of Leukocyte Biology, 1999
Abstract The CC-chemokine receptor 5 (CCR5) mediates activation of T lymphocytes and macrophages by chemokines and is a major co-receptor for macrophage-tropic HIV-1 strains. Recently, it was shown that the natural CCR5 ligands RANTES, macrophage inflammatory protein-1á (MIP-1á), MIP-1β, and amino-terminal modifications of RANTES (Met ...
H, Olbrich, A E, Proudfoot, M, Oppermann
openaire   +2 more sources

A homeostatic function of CXCR2 signalling in articular cartilage [PDF]

, 2014
Funding This work was funded by Arthritis Research UK (grants 17859, 17971, 19654), INNOCHEM EU FP6 (grant LSHB-CT-2005-51867), MRC (MR/K013076/1) and the William Harvey Research FoundationPeer reviewedPublisher ...
Aberdeen, Bertrand, J, Brandolini, L, De Bari, C, Dell'Accio, F, Dompe SPA, Karystinou, A, KU Leuven, Luyten, F P, Muenster, Nalesso, G, Pap, T, Pitsillides, A A, Pitzalis, C, Poulet, B, Queen Mary London, Sherwood, J, UCL   +17 more
core   +3 more sources