Results 41 to 50 of about 94,878 (326)

The role of CXCR4 signaling in the migration of transplanted oligodendrocyte progenitors into the cerebral white matter

Neurobiology of Disease, 2011
Enhancing the ability of either endogenous or transplanted oligodendrocyte progenitors (OPs) to engage in myelination may constitute a novel therapeutic approach to demyelinating diseases of the brain.
Ghazal Banisadr, Terra J. Frederick, Caroline Freitag, Dongjun Ren, Hosung Jung, Stephen D. Miller, Richard J. Miller   +6 more
doaj   +1 more source

Macrophage-derived Chemokine Is a Functional Ligand for the CC Chemokine Receptor 4 [PDF]

Journal of Biological Chemistry, 1998
Macrophage-derived chemokine (MDC) is a recently identified member of the CC chemokine family. MDC is not closely related to other chemokines, sharing most similarity with thymus- and activation-regulated chemokine (TARC), which contains 37% identical amino acids.
Miyuki Nishimura, Osamu Yoshie, David Chantry, Toshio Imai, Carol J. Raport, Patrick W. Gray, Christi L. Wood, Ronald Godiska   +7 more
openaire   +3 more sources

HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism. [PDF]

PLoS ONE, 2014
Human and Simian Immunodeficiency virus (HIV-1, HIV-2, and SIV) encode an accessory protein, Nef, which is a pathogenesis and virulence factor. Nef is a multivalent adapter that dysregulates the trafficking of many immune cell receptors, including ...
Prabha Chandrasekaran, Victoria Moore, Monica Buckley, Joshua Spurrier, John H Kehrl, Sundararajan Venkatesan   +5 more
doaj   +1 more source

The binding and specificity of chemokine binding proteins, through the lens of experiment and computation

Biomedical Journal, 2022
Chemokines are small proteins that are critical for immune function, being primarily responsible for the activation and chemotaxis of leukocytes. As such, many viruses, as well as parasitic arthropods, have evolved systems to counteract chemokine ...
Lauren E. Stark, Wenyan Guan, Michael E. Colvin, Patricia J. LiWang   +3 more
doaj   +1 more source

Eotaxin-3/CCL26 Is a Natural Antagonist for CC Chemokine Receptors 1 and 5

Journal of Biological Chemistry, 2004
Eotaxin-3 (CCL26), like eotaxin (CCL11) and eotaxin-2 (CCL24), has long been considered a specific agonist for CC chemokine receptor 3 (CCR3), attracting and activating eosinophils, basophils, and Th2 type T lymphocytes.
Vibor Petkovic, Christian Moghini, S. Paoletti, M. Uguccioni, B. Gerber   +4 more
semanticscholar   +1 more source

Genomic organization, annotation, and ligand-receptor inferences of chicken chemokines and chemokine receptor genes based on comparative genomics

BMC Genomics, 2005
Background Chemokines and their receptors play important roles in host defense, organogenesis, hematopoiesis, and neuronal communication. Forty-two chemokines and 19 cognate receptors have been found in the human genome.
Sze Sing-Hoi, Yilmaz Ahmet, Adelson David L, Wang Jixin, Jin Yuan, Zhu James J   +5 more
doaj   +1 more source

Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3.

Journal of Immunology, 1996
The chemokines are a large family of cytokines that regulate the complex and precise recruitment of immune cells into inflammatory foci. To fully appreciate their role in the pathogenesis of human diseases, the entire spectrum of chemokines, their ...
E. García-Zepeda, C. Combadière, M. Rothenberg, M. N. Sarafi, F. Lavigne, Q. Hamid, P. M. Murphy, A. Luster   +7 more
semanticscholar   +1 more source

CC chemokine receptors 1 and 3 are differentially regulated by IL-5 during maturation of eosinophilic HL-60 cells.

Journal of Immunology, 1998
CC chemokine receptors 1 and 3 (CCR1 and CCR3) are expressed by eosinophils; however, factors regulating their expression and function have not previously been defined.
H. Tiffany, G. Alkhatib, C. Combadière, E. Berger, P. M. Murphy   +4 more
semanticscholar   +1 more source

Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment

Mediators of Inflammation, 2015
Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and
Sezin Günaltay, Ashok Kumar Kumawat, Nils Nyhlin, Johan Bohr, Curt Tysk, Olof Hultgren, Elisabeth Hultgren Hörnquist   +6 more
doaj   +1 more source

Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.

PLoS Biology, 2019
Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-
Kit Ming Lee, Gillian J Wilson, Marieke Pingen, Ayumi Fukuoka, Christopher A H Hansell, Robin Bartolini, Laura Medina-Ruiz, Gerard J Graham   +7 more
doaj   +1 more source