Results 51 to 60 of about 94,878 (326)

Monocyte Chemoattractant Protein-3 Is a Functional Ligand for CC Chemokine Receptors 1 and 2B (*)

Journal of Biological Chemistry, 1995
The CC chemokine monocyte chemoattractant protein-3 (MCP-3) activates human monocytes, lymphocytes, basophils, and eosinophils. MCP-3 has been reported to induce [Ca] changes in cells transfected with the monocyte-selective MCP-1 receptor 2B (CC CKR2B ...
C. Combadière, S. Ahuja, J. Van Damme, H. Tiffany, Ji-Liang Gao, P. Murphy   +5 more
semanticscholar   +1 more source

Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility.

PLoS Pathogens, 2009
While most chemokine receptors fail to cross the chemokine class boundary with respect to the ligands that they bind, the human cytomegalovirus (HCMV)-encoded chemokine receptor US28 binds multiple CC-chemokines and the CX(3)C-chemokine Fractalkine. US28
Jennifer Vomaske, Ryan M Melnychuk, Patricia P Smith, Joshua Powell, Laurel Hall, Victor DeFilippis, Klaus Früh, Martine Smit, David D Schlaepfer, Jay A Nelson, Daniel N Streblow   +10 more
doaj   +1 more source

Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3– and CC chemokine receptor 4–independent manner

Journal of Allergy and Clinical Immunology, 1999
Chemokines are believed to contribute to selective cell recruitment. Macrophage-derived chemokine (MDC) is a CC chemokine that causes chemotaxis of dendritic cells, monocytes, and activated natural killer cells. MDC binds to CC chemokine receptor 4 (CCR4) but not to CCR1, CCR2, CCR3, CCR5, CCR6, or CCR7.Our aim was to determine the in vitro activity of
Patrick W. Gray, Bruce S. Bochner, Donald W. MacGlashan, Ronald Godiska, Marcia L. Taylor, Carol A. Bickel, Carol J. Raport   +6 more
openaire   +3 more sources

Duffy Antigen Receptor for Chemokines (DARC) and its Involvement in Patterning and Control of Inflammatory Chemokines

Frontiers in Immunology, 2012
Leukocyte functions are linked to their migratory responses, which, in turn, are largely determined by the expression profile of classical chemokine receptors.
Igor eNovitzky-Basso, Antal eRot
doaj   +1 more source

Identification of key biomarkers and related immune cell infiltration in cervical cancer tissue based on bioinformatics analysis

Scientific Reports, 2023
Cervical cancer (CC) is the most common gynecological malignant tumor. Immunotherapy has become a new model for the treatment of CC, especially advanced and recurrent cancer. At present, many studies are exploring the safety and efficacy of immunotherapy
Guang Zhu, Zhihui Xiong, Wenzeng Chen, Zhen Zhu, Wei Wang   +4 more
doaj   +1 more source

The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4 [PDF]

Journal of Biological Chemistry, 1997
Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a class of receptors binding TARC with high affinity and specificity.
Osamu Yoshie, Miyuki Nishimura, Masataka Baba, Mayumi Kakizaki, Toshio Imai, Shin Takagi   +5 more
openaire   +3 more sources

Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine–CCR5 interactions [PDF]

Antiviral Therapy, 2009
Background This study aimed to examine how CC chemokine receptor 5 (CCR5) inhibitors (aplaviroc [APL], TAK779 and maraviroc [MVC]) interact with CCR5 and affect its dynamics and physiological CC-chemokine–CCR5 interactions. Methods A yellow fluorescent protein (YFP)-tagged CCR5-expressing U373-MAGI cell line was generated and a stable CCR5-expressing ...
Hirotomo Nakata, Hiromi Ogata-Aoki, Michael J. Kruhlak, Jianfeng Li, Hiroaki Mitsuya, Wakako Kamata, Arun K. Ghosh, Kenji Maeda   +7 more
openaire   +2 more sources

CC Chemokine and CC Chemokine Receptor Profiles in Visceral and Subcutaneous Adipose Tissue Are Altered in Human Obesity [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2008
Obesity is associated with a low-grade inflammation, insulin resistance, and macrophage infiltration of adipose tissue. The role of CC chemokines and their respective receptors in human adipose tissue inflammation remains to be determined.sc and visceral adipose tissue of obese patients (body mass index 53.1 +/- 11.3 kg/m(2)) compared with lean ...
Joakim Huber, Bernhard Ludvik, Gerhard Prager, Thomas M. Stulnig, Gerhard J. Zlabinger, Maximilian Zeyda, Gerd R. Silberhumer, Florian W. Kiefer   +7 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source