Results 71 to 80 of about 208,608 (296)

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

open access: yesAdvanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen   +11 more
wiley   +1 more source

FARELO DE ARROZ INTEGRAL EM RAÇÕES PARA LEITÕES DE 43 A 67 DIAS DE IDADE

open access: yesCiência Animal Brasileira, 2012
Foram utilizados 64 leitões, fêmeas e machos castrados, de linhagem comercial, com média de 43 dias de idade e com peso inicial médio de 10,73 ± 1,85 kg, com o objetivo de se avaliar os efeitos da inclusão de farelo de arroz integral (FAI) na ração até ...
Thalles Ribeiro Gomes   +5 more
doaj   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu   +4 more
wiley   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

open access: yesAdvanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li   +12 more
wiley   +1 more source

Ní­­veis de energia metabolizável para rações de rã touro

open access: yesBoletim do Instituto de Pesca, 2018
O objetivo do presente estudo foi avaliar os efeitos da interação entre o ní­­vel de proteí­­na bruta (PB) e de energia metabolizável (EM) na ração de rãs através do desempenho dos animais (ganho de peso, consumo alimentar, conversão alimentar) e do ...
Josevane Carvalho CASTRO   +3 more
doaj  

Seasonal dynamics of benthic macroinvertebrate assemblages and water quality in Lake Sapanca (Türkiye): A multimetric assessment

open access: yesOceanological and Hydrobiological Studies
This study examined spatial and seasonal variation of benthic macroinvertebrate assemblages in Lake Sapanca, based on samples from five stations during spring, summer, and autumn 2020, and winter 2021. Physicochemical parameters, including pH, electrical
Şahin Serap Koşal   +1 more
doaj   +1 more source

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

open access: yesAdvanced Science, EarlyView.
This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu   +12 more
wiley   +1 more source

Uso de lodo de esgoto e resíduos orgânicos no crescimento de mudas de Sesbania virgata (Cav.) Pers.

open access: yesAgro@mbiente On-line, 2013
Na fase de produção de mudas, o substrato exerce influência significativa no crescimento das plantas, e sua utilização pode ser feita de forma original ou combinados, tornando necessário, estudos voltados para obtenção de substratos capazes de garantir ...
William Macedo Delarmelina   +3 more
doaj   +1 more source

On the Security of Multiple Encryption or CCA-security+CCA-security=CCA-security? [PDF]

open access: yes, 2003
In a practical system, a message is often encrypted more than once by different encryptions, here called multiple encryption, to enhance its security. Additionally, new features may be achieved by multiple encrypting a message for a scheme, such as the ...
Rui Zhang   +3 more
core  

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

open access: yesAdvanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang   +18 more
wiley   +1 more source

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