Results 121 to 130 of about 87,027 (145)

MiR-148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl-2

Tumor Biology, 2013
Our previous studies have revealed that miR-148a is downregulated in pancreatic cancer. Bioinformatics analysis has shown cholecystokinin-B receptor (CCKBR) and B cell lymphoma (Bcl-2) to be potential targets of miR-148a. But the pathophysiologic role of miR-148a and its relevance to the growth and development of pancreatic cancer are yet to be ...
Guoqiang Zhao, Wenqiao Zang, Du Yuwen
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Trastuzumab Inhibits Growth of HER2-Negative Gastric Cancer Cells Through Gastrin-Initialized CCKBR Signaling

Digestive Diseases and Sciences, 2015
Administration of trastuzumab, a fully humanized monoclonal antibody targeted to the human epidermal growth factor receptor 2 (HER2, p185), has improved outcomes for patients with HER2-positive gastric cancer (GC), but some relevant issues remain to be investigated and will emerge with new anti-GC drugs.
Xingchun Peng, Guohui Fu, Fu Guo-Hui
exaly   +3 more sources

Downregulation of CCKBR Expression Inhibits the Proliferation of Gastric Cancer Cells, Revealing a Potential Target for Immunotoxin Therapy

Current Cancer Drug Targets, 2022
Background: Increased CCKBR expression density or frequency has been reported in many neoplasms. Objective: We aimed to investigate whether CCKBR drives the growth of gastric cancer (GC) and its potential as a therapeutic target of immunotoxins. Methods: A lentiviral interference system was used to generate CCKBR-knockdown gastric cancer cells ...
Meng, Li, Jiang, Chang, Honglin, Ren, Defeng, Song, Jian, Guo, Lixiong, Peng, Xiaoshi, Zhou, Ke, Zhao, Shiying, Lu, Zengshan, Liu, Pan, Hu   +10 more
openaire   +2 more sources

Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment

Cell
Expressed in the entorhinal cortex (EC), the cholecystokinin (CCK) B receptor (CCKBR) plays an important role in memory and learning. Here, we identify that CCKBR-Gs and -Gq signaling, rather than CCKBR-Gi signaling, are beneficial for Alzheimer's disease (AD) treatment.
Xin-Yi Xia
exaly   +3 more sources

Polymorphisms of the CCK, CCKAR and CCKBR genes: an association with alcoholism study.

Journal of Studies on Alcohol, 2001
Cholecystokinin (CCK) plays an important role in the functioning of the central nervous system via an interaction with dopamine and other neurotransmitters. The dopaminergic system has been implicated in the maladaptive behaviors associated with drugs of abuse (e.g., alcohol and cocaine).
T, Okubo, S, Harada
openaire   +2 more sources

Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na + /H + Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway

Hypertension, 2022
The present study directly tested the crucial role of intestinal gastrin/CCKBR (cholecystokinin B receptor) in the treatment of salt-sensitive hypertension.Adult intestine-specific Cckbr-knockout mice (Cckbrfl/fl villin-Cre) and Dahl salt-sensitive rats were studied on the effect of high salt intake (8% NaCl, 6-7 weeks) on intestinal Na+/H+ exchanger 3
Xiaoliang Jiang, Zhiwei Yang, Shun Duan   +2 more
exaly   +3 more sources

215-OR: Silencing CCKBR Containing Neurons in the VMN Restrains Hepatic Glucose Production to Ameliorate Diabetes in Mice

Diabetes, 2020
Optimal glucose control remains elusive for many patients with diabetes despite current therapies, necessitating the development of novel therapeutic modalities. While the central nervous system (CNS) plays a crucial role in glucose homeostasis, specific CNS targets for therapeutic intervention in diabetes have remained elusive.
ALISON AFFINATI, JONATHAN FLAK, NADEJDA BOZADJIEVA, NANDAN KODUR, CORENTIN M. CRAS-MÉNEUR, DARLEEN A. SANDOVAL, MARTIN G. MYERS   +6 more
openaire   +1 more source

Cholecystokinin (CCK) mediates CCKBR to regulate androgen secretion via the steroid pathway in Bactrian camel Sertoli cells

Journal of Steroid Biochemistry and Molecular Biology
This study aimed to identify differentially expressed genes (DEGs) in the testes of Bactrian camels during estrus and anestrus and investigate the regulatory role of cholecystokinin (CCK) and its receptor (CCKBR) in androgen synthesis. RNA sequencing was performed on six testicular samples (estrus, n = 3; anestrus, n = 3).
Xingxu Zhao
exaly   +3 more sources

Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5→p15.4 by fluorescence in situ hybridization

Cytogenetics and Cell Genetics, 2008
A human cholecystokinin-B/gastrin receptor cDNA (CCKBR) has been recently cloned and its transcriptional product has been characterized. The cDNA probe was mapped by fluorescence in situ hybridization to chromosome 11 at bands p15.5→p15.4. The localization of this receptor gene provides a useful marker for this region of chromosome 11 permitting the ...
D B, Zimonjic, N C, Popescu, T, Matsui, M, Ito, K, Chihara   +4 more
openaire   +2 more sources

Identification and synthesis of low-molecular weight cholecystokinin B receptor (CCKBR) agonists as mediators of long-term synaptic potentiation

Medicinal Chemistry Research, 2019
Recently, He et al. reported that CCKB receptors located in the neocortex of the brain when bound to their bound natural ligand, CCK peptides, enhance memory, bringing up the possibility that agonists targeting the CCKB receptor may act as therapeutic agents in diseases in which memory loss is marked as observed in dementia and Alzheimer’s.
Zhang, Yanmei, Wang, Yican, Guo, Yiping, Liao, Jinxi, Tu, Zhengchao, Lu, Yongzhi, Ding, Ke, Tortorella, Micky D., He, Jufang   +8 more
openaire   +2 more sources