Results 211 to 220 of about 100,458 (303)

Human Colitis‐on‐Chip Model Reveals Dual Roles of Butyrate in Epithelial and Macrophage Defense Against Candida albicans Tissue Invasion

Small, EarlyView.
This study establishes a human immunocompetent colitis‐on‐chip model that mimics inflamed gut mucosa and enables quantitative analysis of Candida albicans tissue invasion under DSS‐induced injury. It reveals that microbiota‐derived butyrate simultaneously stabilizes epithelial junctions and reprograms macrophages via HDAC/NLRP3‐dependent mechanisms ...
Manuel Allwang, Maximilian Wipplinger, Parastoo Akbarimoghaddam, Raquel Alonso‐Roman, Zoltan Cseresnyes, Axel Dietschmann, Valentin Wegner, Adrian Feile, Yann Bachelot, Maria Warschinke, Mohamed I. Abdelwahab Hassan, Sonnhild Mittag, Otmar Huber, Bernhard Hube, Mark S. Gresnigt, Marc Thilo Figge, Alexander S. Mosig   +16 more
wiley   +1 more source

Fibroblast-mediated KRAS activation in double-negative prostate cancer. [PDF]

Cell Death Dis
Kamijima T, Izumi K, Hiratsuka K, Inaba T, Koketsu Y, Nakagawa R, Toriumi R, Aoyama S, Kano H, Makino T, Naito R, Kadomoto S, Iwamoto H, Yaegashi H, Kawaguchi S, Nohara T, Shigehara K, Nakata H, Saito Y, Nakagawa-Goto K, Lin WJ, Mizokami A.   +21 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms. [PDF]

Drug Des Devel Ther
Sun Y, Yang X, Zhu Q, Yang R.
europepmc   +1 more source

Recovery of Pure PVC From Pharmaceutical Composite Packaging via Dissolution‐Based Recycling

Journal of Vinyl and Additive Technology, EarlyView.
Closed‐loop pathway for pharmaceutical blister waste via selective dissolution‐based recycling (DBR) enables separation of PVDC and aluminum, PVC recovery and reprocessing into films with 30 phr recycled content, and validation for thermoforming applications.
Martin Schlummer, Swetlana Wagner, Franziska Ludwig, Michael Nedelcu, Oliver Paillerau, Thomas Hülsmann   +5 more
wiley   +1 more source

A Botanical Mixture of Boswellia serrata, Commiphora myrrha, Propolis and Scutellaria baicalensis Reduces Expression of Inflammatory Chemokines in Canine Keratinocytes In Vitro. [PDF]

Vet Med Sci
Ha D, Jung K, Choi H, Yoon JS.
europepmc   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Liver Kinase B1 in CD11c⁺ Cells Inhibits Fibrosis in Chronic Pancreatitis via the Oncostatin M Signaling. [PDF]

Adv Sci (Weinh)
Zhang W, Guo S, Zhang Y, Ren H, Lei K, Zhao C, Yu Q, Luo H, Xiao Y, Feng X, Li X.   +10 more
europepmc   +1 more source

Disrupting SRSF10-dependent BCAT2 exon skipping reprograms tumor-associated macrophages and enhances anti-PD-1 efficacy in gastric cancer. [PDF]

Cell Death Dis
Huang XB, Yang XP, Zheng HL, Wang LQ, Jiang CY, Chen YL, Lin B, Li YF, Guo XJ, Huang Q, Gao YX, Li Y, Ye XQ, Wang JB, Xie JW, Lin JX, Zheng CH, Huang CM, Chen QY, Li P.   +19 more
europepmc   +1 more source