Results 231 to 240 of about 100,458 (303)

The potential directing role of chemokines for specific metastatic sites in breast cancer. [PDF]

Sci Rep
Ayoub AM, El-Houseini ME, Tharwat E, Bayomy MFF, Abdellateif MS.   +4 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

The role of C-C motif chemokine ligand 2 in the preservation of myogenic tone in the kidney microvasculature of Dahl Salt-Sensitive rats. [PDF]

Kidney Int
Feng W, Guan Z, Ying WZ, Feng C, Hyndman KA, Sanders PW.   +5 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

ADAMDEC1-driven CCL2-CCR2-PD-1 axis in esophageal squamous cell carcinoma: a dual threat of O-GlcNAcylation and m⁶A methylation in neoadjuvant therapy resistance and immune evasion. [PDF]

Cell Oncol (Dordr)
Cheng J, Ma H, Qian X, Xing W.
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

PRMT6 is required for initiating and amplifying macrophage-induced inflammation in heterotopic ossification by increasing CCL2 expression. [PDF]

Bone Res
Chu W, Peng W, Wu Z, Xiong Y, Gao Z, Li Y, Zhang B, Wang L, Wang H, Han C, Lu X.   +10 more
europepmc   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Heme-induced activation of the TLR3/TRIF-IFN-I-CCL2 pathway contributes to kidney injury in sickle cell disease.

Blood
Liu Y, Shayo S, Su S, Bao W, Zhong H, Murakhovskaya I, Lobo CA, An X, Manwani D, Shi PA, Yazdanbakhsh K.   +10 more
europepmc   +1 more source

Characterizing inflammatory biomarkers in post-stroke seizure risk and outcome prognostication. [PDF]

PLoS One
Wang EY, Misra S, Yan J, Chook PY, Kawamura Y, Kitagawa R, Kim JA, Gilmore EJ, de Havenon A, Sivaraju A, Hirsch LJ, Falcone GJ, Rangaraju S, Sansing LH, Magid-Bernstein J, Mishra NK.   +15 more
europepmc   +1 more source