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CCL2 in the Tumor Microenvironment
2021The C-C motif chemokine ligand 2 (CCL2) is a crucial mediator of immune cell recruitment during microbial infections and tissue damage. CCL2 is also frequently overexpressed in cancer cells and other cells in the tumor microenvironment, and a large body of evidence indicates that high CCL2 levels are associated with more aggressive malignancies, a ...
O'Connor, T., Heikenwälder, M.
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A role for CCL2 in both tumor progression and immunosurveillance [PDF]
OncoImmunology, 2013 The chemokine CCL2, which is best known for its chemotactic functions, is expressed not only by immune cells, but also by several types of malignant and stromal cells. CCL2 has been shown to exert both pro- and anti-tumor effects. However, recent results
Mark J. Smyth +2 more
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Nitration of CCL2 disrupts the tumor-protective function of CCL2 in bladder cancer
The Journal of Immunology, 2022Abstract The chemokine CCL2 (C-C motif ligand 2) is best known for its ability to induce trafficking of immune cells by binding its primary receptor, CCR2. The recruitment of immunosuppressive monocytes by CCL2 promotes cancer in several tumor types. Surprisingly, we previously found an unanticipated protective role for CCL2 signaling in
Neelam Mukherjee +4 more
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ChemInform, 1987
AbstractFluorination of the perchlorodiazahexadiene (I) yields the imidazolines (III) or (IV), depending on the amount of the fluorinating agent SbF5 (II) used.
G. PAWELKE +3 more
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AbstractFluorination of the perchlorodiazahexadiene (I) yields the imidazolines (III) or (IV), depending on the amount of the fluorinating agent SbF5 (II) used.
G. PAWELKE +3 more
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Chemical Physics Letters, 2008
Abstract The kinetics of the CCl2 + Br2 and CCl2 + NO2 reactions have been studied at temperatures between 266 and 365 K using laser photolysis/photoionization mass spectrometry. Dichloromethylene biradicals were produced by the pulsed laser photolysis of CCl4.
Arkke J. Eskola +3 more
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Abstract The kinetics of the CCl2 + Br2 and CCl2 + NO2 reactions have been studied at temperatures between 266 and 365 K using laser photolysis/photoionization mass spectrometry. Dichloromethylene biradicals were produced by the pulsed laser photolysis of CCl4.
Arkke J. Eskola +3 more
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CCL2 (monocyte chemoattractant protein-1) and cancer
Seminars in Cancer Biology, 2004Genetic analyses of cancer in humans indicate that chemokines and their receptors are unlikely to play direct roles in pathogenesis. However, these molecules have pleiotropic effects that impact on cancer pathobiology in animal models, and there is evidence that they may do the same in humans. Given their protean properties, chemokines could have tumor-
Barrett J Rollins
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Journal AWWA, 2008
On July 30, 2008, the U.S. Environmental Protection Agency (USEPA) finalized the regulatory determinations for 11 contaminants on the Second Contaminant Candidate List (CCL2). Considering the best available data, USEPA concluded that these contaminants occur infrequently at levels of public health concern in public water systems.
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On July 30, 2008, the U.S. Environmental Protection Agency (USEPA) finalized the regulatory determinations for 11 contaminants on the Second Contaminant Candidate List (CCL2). Considering the best available data, USEPA concluded that these contaminants occur infrequently at levels of public health concern in public water systems.
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Synthesis of aromatic compounds of types ArCH2CH = CCl2 and Ar?(CH2CH = CCl2)2
Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 19591. The condensation of 1,1,3-trichloro-1-propene with benzene, toluene, 3-phenyl-1,1-dichloro-1-propene, 3-(p-chlorophenyl)-1,1-dichloro-1-propene, naphthalene and 3-phenyl-1,1,1,2-tetrachloropropane was carried out in the presence of aluminum chloride or antimony pentachloride, with the formation of the corresponding mono- and di-alkylated products.
R. Kh. Freidlina +2 more
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Association of CCL2 Gene Variants with Osteoarthritis
Archives of Medical Research, 2019The chemokine (C-C motif) Ligand 2 (CCL2)/CCR2 signaling was associated with macrophage accumulation, synovitis and cartilage damage in a mouse osteoarthritis (OA) model.Here a case-control study in a Chinese Han population was conducted to investigate the possible association between the CCL2 gene polymorphism and risk of OA.
Zhonghua, Xu +6 more
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