Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3 [PDF]
Cell Discovery, 2022 Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao +21 more
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Anterograde Trafficking of CXCR4 and CCR2 Receptors in a Prostate Cancer Cell Line [PDF]
Cellular Physiology and Biochemistry, 2013 Background: Most prostate cancer-related deaths result from metastasis. CXCR4 and CCR2 are known to govern cellular processes resulting in cell migration, proliferation and survival.
Kelsie Gillies +3 more
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Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury
American Journal of Physiology - Renal Physiology, 2011 Monocyte/macrophage recruitment correlates strongly with the progression of renal impairment in diabetic nephropathy (DN). C-C chemokine receptor (CCR)2 regulates monocyte/macrophage migration into injured tissues. However, the direct role of CCR2-mediated monocyte/macrophage recruitment in diabetic kidney disease remains unclear.
Alaa S Awad, Gilbert R Kinsey
exaly +4 more sources
Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]
PLoS Computational Biology, 2018 Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer +2 more
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Evolution of CCR5 and CCR2 Genes in Bats Showed Multiple Independent Gene Conversion Events
Viruses, 2022 Chemokine receptors are an important determinant for the infectiousness of different pathogens, which are able to target the host cells by binding to the extracellular domains of these proteins.
Alexandre P. Fernandes +4 more
doaj +1 more source
Arteriolar and venular remodeling are differentially regulated by bone marrow-derived cell-specific CX3CR1 and CCR2 expression. [PDF]
PLoS ONE, 2012 The chemokine receptors CCR2 and CX3CR1 are critical for the recruitment of "inflammatory" and "resident" monocytes, respectively, subpopulations that differentially affect vascular remodeling in atherosclerosis.
Joshua K Meisner +2 more
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Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico study. [PDF]
PLoS ONE, 2012 Chemokine receptors are G protein-coupled receptors that contain seven transmembrane domains. In particular, CCR2 and CCR5 and their ligands have been implicated in the pathophysiology of a number of diseases, including rheumatoid arthritis and multiple ...
Gugan Kothandan +2 more
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Phosphorylation of filamin A regulates chemokine receptor CCR2 recycling [PDF]
Journal of Cell Science, 2017 ABSTRACT Proper endosomal trafficking of ligand-activated G-protein-coupled receptors (GPCRs) is essential to spatiotemporally tune their physiological responses. For the monocyte chemoattractant receptor 2 (CCR2B; one of two isoforms encoded by CCR2), endocytic recycling is important to sustain monocyte migration, whereas filamin A ...
Pons, Mónica +8 more
openaire +4 more sources
Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease. [PDF]
PLoS ONE, 2015 Understanding functional interactions between G protein-coupled receptors is of great physiological and pathophysiological importance. Heteromerization provides one important potential mechanism for such interaction between different signalling pathways ...
Mohammed Akli Ayoub +8 more
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Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis. [PDF]
PLoS ONE, 2011 BACKGROUND: The aim of this study was to provide more insight into the question as to why blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid arthritis (RA) patients, using an in vitro monocyte migration system model ...
Maria C Lebre +8 more
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